B9685

BAY 61-3606 hydrochloride hydrate

≥98% (HPLC), powder

• Synonyme(s) : 2-[[7-(3,4-Dimethoxyphenyl)imidazo[1,2-c]pyrimidin-5-yl]amino]pyridine-3-carboxamide hydrochloride
• Formule empirique (notation de Hill): C₂₀H₁₈N₆O₃ · xHCl · yH₂O
• Poids moléculaire : 390.40 (anhydrous free base basis)
• Code UNSPSC : 12352200
• ID de substance PubChem : 24724427
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Pureté: ≥98% (HPLC)
• Forme: powder
• Puissance: 7.5 nM K_i
• Conditions de stockage: desiccated
• Couleur: yellow
• Solubilité: H₂O: soluble
• Auteur: Bayer
• Température de stockage: 2-8°C
• Chaîne SMILES: O.Cl.COc1ccc(cc1OC)-c2cc3nccn3c(Nc4ncccc4C(N)=O)n2
• InChI: 1S/C20H18N6O3.ClH.H2O/c1-28-15-6-5-12(10-16(15)29-2)14-11-17-22-8-9-26(17)20(24-14)25-19-13(18(21)27)4-3-7-23-19;;/h3-11H,1-2H3,(H2,21,27)(H,23,24,25);1H;1H2
• Clé InChI: WYXPKEXHEJAVSI-UHFFFAOYSA-N

Description

Application

BAY 61-3606 hydrochloride hydrate has been used in focal cerebral ischemia model. It has also been used to assess the effect of Syk in stroke-induced injury.

Actions biochimiques/physiologiques

BAY 61-3606 helps to prevent the degranulation of freshly isolated basophils. It also prevents B cell receptor (BCR)-mediated signaling.

Spleen tyrosine kinase (Syk) inhibitor; anti-inflammatory. Syk plays a major role in inflammation pathways via receptors for the Fc portion of immunoglobulins, as well as B cell signaling. It is orally active, potent (Ki 7.5 nM), and highly selective for Syk vs other kinases (Lyn, Fyn, Src, Itk, Btk; Ki′s).

Caractéristiques et avantages

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by Bayer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)