Accéder au contenu
Merck
Toutes les photos(2)

Documents

B0189

Sigma-Aldrich

Casticin

from Vitex trifolia, ≥98% (HPLC)

Synonyme(s) :

Casticine, Quercetagetin 3,6,7,4′-tetramethyl ether, Vitexicarpin

Se connecterpour consulter vos tarifs contractuels et ceux de votre entreprise/organisme
Toutes les photos(2)

About This Item

Formule empirique (notation de Hill):
C19H18O8
Numéro CAS:
479-91-4
Poids moléculaire :
374.34
Code UNSPSC :
12352200
Nomenclature NACRES :
NA.25

Source biologique

Vitex trifolia

Pureté

≥98% (HPLC)

Forme

powder

Solubilité

ethanol: 1 mg/mL, clear, colorless to light yellow

Application(s)

metabolomics
vitamins, nutraceuticals, and natural products

Température de stockage

2-8°C

InChI

1S/C19H18O8/c1-23-11-6-5-9(7-10(11)20)17-19(26-4)16(22)14-12(27-17)8-13(24-2)18(25-3)15(14)21/h5-8,20-21H,1-4H3

Clé InChI

PJQLSMYMOKWUJG-UHFFFAOYSA-N

Description générale

Casticin is one of the flavonoids present in the traditional Chinese medicine Inula japonica Thunb. It is a polymethyl compound with three rings, a catechol moiety at ortho position, one double bond, two hydroxyl groups, and four methoxy groups. It has been isolated from the fruits, seeds, and leaves of various Vitex species.

Application

Casticin from Vitex trifolia is used to study its mechanisms of action as an antiiflammatory and anticancer agent via processes such as TRAIL-induced apoptosis, cell cycle arrest, ROS generation, and glutathione (GSH) depletion.

Actions biochimiques/physiologiques

Casticin has anticancer, pro-apoptotic, anti-proliferative, anti-asthmatic, and anti-angiogenic properties. In addition, it exhibits anti-inflammatory behavior by means of its inhibitory effect on lipoxygenases and T- & B-lymphocytes. Due to its oestrogenic activity, it is being used to manage Premenstrual syndrome in women. It is also reported to mitigate rheumatoid arthritis and liver fibrosis manifestations.
Tubulin-binding anticancer flavonoid. Casticin induces apoptosis in cancer cells.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

Déjà en possession de ce produit ?

Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Flavonoids from the aerial parts of Inula japonica
Qin J, et al.
Chinese Journal of Natural Medicines, 8, 257-259 (2010)
Lihua He et al.
Oncology reports, 29(1), 103-108 (2012-10-16)
Casticin, a polymethoxyflavone, has been reported to exert anticancer activities. The objectives of this study were to examine the molecular mechanisms by which casticin induces the growth inhibition and cell cycle arrest in human hepatocellular carcinoma (HCC) cells. The HCC
Yuan Hu et al.
The Journal of pharmacy and pharmacology, 59(9), 1307-1312 (2007-09-22)
The ethanol extract of the fruits of Vitex rotundifolia (VRE) and its four major compounds (casticin, luteolin, rotundifuran and agnuside) were tested for their estrogen-like activity by using the modified cell proliferation assay (E-SCREEN assessment system), as well as the
Jun Yang et al.
World journal of gastroenterology, 17(38), 4298-4307 (2011-11-18)
To investigate the apoptotic activities of casticin in hepatocellular carcinoma (HCC) cells and its molecular mechanisms. PLC/PRF/5 and Hep G2 cell lines were cultured in vitro and the inhibitory effect of casticin on the growth of cells was detected by
Chiara Righeschi et al.
Cancer genomics & proteomics, 9(3), 143-151 (2012-05-18)
Natural polyphenols play an important role in tumor inhibition. We used a doxorubicin-sensitive acute T-lymphoblastic leukemia cell line (CCRF-CEM) and its multidrug-resistant subline (CEM/ADR5000) to evaluate the activity of 15 plant polyphenols isolated in our laboratory (hypericin and pseudohypericin, verbascoside
Afficher tous les articles scientifiques apparentés

Notre équipe de scientifiques dispose d'une expérience dans tous les secteurs de la recherche, notamment en sciences de la vie, science des matériaux, synthèse chimique, chromatographie, analyse et dans de nombreux autres domaines..

Contacter notre Service technique