Accéder au contenu
Merck
Toutes les photos(1)

Principaux documents

APREST71076

Sigma-Aldrich

PrEST Antigen XRCC4

Prestige Antigens™ Powered by Atlas Antibodies, buffered aqueous solution

Se connecterpour consulter vos tarifs contractuels et ceux de votre entreprise/organisme
Toutes les photos(1)

About This Item

Code UNSPSC :
12352202

Produit recombinant

expressed in E. coli

Essai

>80% (SDS-PAGE)

Forme

buffered aqueous solution

Poids mol.

predicted mol wt 33 kDa

Produit purifié par

immobilized metal affinity chromatography (IMAC)

Concentration

≥0.5 mg/mL

Séquence immunogène

KCVSAKEALETDLYKRFILVLNEKKTKIRSLHNKLLNAAQEREKDIKQEGETAICSEMTADRDPVYDESTDEESENQTDLSGLASAAVSKDDSIISSLDVTDIAPSRKRRQRMQRNLGTEPKMAPQENQLQEK

Numéro d'accès Ensembl | humain

ENSG00000152422

Numéro d'accès UniProt

Q13426

Conditions d'expédition

wet ice

Température de stockage

−20°C

Informations sur le gène

human ... XRCC4(7518)

Description générale

Recombinant protein fragment of Human XRCC4 with N-terminal His6ABP (ABP = Albumin Binding Protein derived from Streptococcal Protein G) fusion tag. X-ray repair cross-complementing protein 4 (XRCC4) is also known as DNA repair protein XRCC4. It is mapped to human chromosome locus 5q14.2. It mediates joining of DNA double strand breaks during DNA repair.

Application

Suitable as a blocking agent using corresponding antibodies.

Actions biochimiques/physiologiques

X-ray repair cross-complementing protein 4 (XRCC4) interacts with XRCC4-like factor (XLF) and DNA ligase IV in mediating nonhomologous end joining (NHEJ) cascade in DNA repair. A mutation in the XRCC4 is associated with adult-onset progressive encephalocardiomyopathy and ataxia. Patients with polymorphisms in XRCC4 gene are susceptible to schizophrenia. Single nucleotide polymorphisms in XRCC4 associates with high risk for cancer development. Mutations in XRCC4 leads to growth failure resulting in short stature accompanied by facial dysmorphism.(10)

Liaison

Corresponding Antibody HPA006801.

Forme physique

Solution in 1 M urea-PBS, pH 7.4

Notes préparatoires

The protein solution should be gently mixed before use. Optimal concentrations and conditions for each application should be determined by the user.

Informations légales

Prestige Antigens is a trademark of Sigma-Aldrich Co. LLC

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Faites votre choix parmi les versions les plus récentes :

Certificats d'analyse (COA)

Lot/Batch Number

It looks like we've run into a problem, but you can still download Certificates of Analysis from our Documents section.

Si vous avez besoin d'assistance, veuillez contacter Service Clients

Déjà en possession de ce produit ?

Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Mutations in XRCC4 cause primary microcephaly, short stature and increased genomic instability
Rosin N, et al.
Human Molecular Genetics, 24(13), 3708-3717 (2015)
An updated meta-analysis of XRCC4 polymorphisms and cancer risk based on 31 case-control studies
Shao N, et al.
Cancer Biomarkers : Section A of Disease Markers, 12(1), 37-47 (2013)
Sliding sleeves of XRCC4-XLF bridge DNA and connect fragments of broken DNA
Brouwer I, et al.
Nature, 535(7613), 566-566 (2016)
Cernunnos interacts with the XRCC4
Callebaut I, et al.
The Journal of Biological Chemistry, 281(20), 13857-13860 (2006)
XRCC4 deficiency in human subjects causes a marked neurological phenotype but no overt immunodeficiency
Guo C, et al.
The Journal of Allergy and Clinical Immunology, 136(4), 1007-1017 (2015)
Afficher tous les articles scientifiques apparentés

Notre équipe de scientifiques dispose d'une expérience dans tous les secteurs de la recherche, notamment en sciences de la vie, science des matériaux, synthèse chimique, chromatographie, analyse et dans de nombreux autres domaines..

Contacter notre Service technique