435R-1

MCM3 (EP202) Rabbit Monoclonal Primary Antibody

• Code UNSPSC : 12352202
• Nomenclature NACRES : NA.41

Propriétés

• Source biologique: rabbit
• Conjugué: unconjugated
• Forme d'anticorps: culture supernatant
• Type de produit anticorps: primary antibodies
• Clone: EP202, monoclonal
• Description: (For In Vitro Diagnostic Use in Select Regions (See Chart))
• Forme: buffered aqueous solution
• Espèces réactives: human
• Conditionnement: vial of 0.1 mL concentrate (435R-14); vial of 0.5 mL concentrate (435R-15); bottle of 1.0 mL predilute (435R-17); vial of 1.0 mL concentrate (435R-16); bottle of 7.0 mL predilute (435R-18)
• Fabricant/nom de marque: Cell Marque^®
• Technique(s): immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100
• Isotype: IgG
• Contrôle: tonsil
• Conditions d'expédition: wet ice
• Température de stockage: 2-8°C
• Visualisation: nuclear
• Informations sur le gène: human ... MCM3(4172)

Description

Description générale

MCM3, minichromosome maintenance protein 3, belongs to the MCM family of highly conserved group of DNA-binding proteins known to have a role in the initiation and regulation of DNA replication during the cell cycle.^1-7 MCM3 expression is up-regulated in proliferating cells and absent in terminally differentiated cells. Like Ki-67, MCM3 marks proliferating cells. In a study performed by Endl E., et al., Ki-67 and MCM3 double staining was performed on human tonsil showing that MCM3 stains proliferating cells like Ki-67, and in addition marks cells present in the intermediate layer of epithelium (which are typically negative for Ki-67). Both Ki-67 and MCM3 are not detectable in differentiated cells.⁶ However, unlike Ki-67, MCM3 protein down-regulation is delayed. This suggests that Ki-67 may be expressed during a shorter interval of the cell cycle than MCM3. Anti-MCM3 may be a more reliable proliferation marker than anti-Ki-67.¹

Qualité

IVD

IVD

IVD

RUO

Liaison

MCM3 Positive Control Slides, Product No. 435S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Forme physique

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Notes préparatoires

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Autres remarques

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Informations légales

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany