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Principaux documents

COO/COA

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43405

β-Nicotinamide-adénine-dinucléotide hydrate

Name: β-Nicotinamide-adénine-dinucléotide hydrate
Brand: SIGMA

≥99.0% (HPLC), from yeast

Synonyme(s) :

β-DPN, β-NAD, Coenzyme 1, Cozymase, DPN, Diphosphopyridine nucléotide, NAD, Nadide

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About This Item

Formule empirique (notation de Hill):

C₂₁H₂₇N₇O₁₄P₂ · xH₂O

Numéro CAS:

53-84-9

Poids moléculaire :

663.43 (anhydrous basis)

Numéro CE :

200-184-4

Numéro MDL:

MFCD00036253

Code UNSPSC :

12352200

eCl@ss :

39200202

Source biologique

yeast

Essai

≥99.0% (HPLC)

Impuretés

≤0.1% solvent
≤10% water

Solubilité

H₂O: 50 mg/mL, clear, colorless

Rapport des absorbances

A_280/260 nm 0.22 ±0.02
A_250/260 nm 0.83 ±0.03

Adéquation

in accordance for determination of ADH

Température de stockage

−20°C

Chaîne SMILES

NC1=NC=NC2=C1N=CN2.O[C@@H]3[C@@H](COP(O)(OP(OC[C@@H](O4)[C@@H](O)[C@@H](O)[C@H]4[N+]5=CC=CC(C(N)=O)=C5)([O-])=O)=O)OC[C@@H]3O

InChI

1S/C21H27N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1-4,7-8,10-11,13-16,20-21,29-32H,5-6H2,(H5-,22,23,24,25,33,34,35,36,37)/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1

Clé InChI

BAWFJGJZGIEFAR-NNYOXOHSSA-N

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Application

Nicotinamide adenine dinucleotide (NAD) and NADH form a redox pair. NAD/NADH is a coenzyme that supports redox reactions via the transport of electrons in a vast array of applications. NAD is also involved in post-translational (Poly(ADP-ribose) polymerization) modifications of proteins.

Actions biochimiques/physiologiques

Accepteur d'électrons

Conditionnement

Produit conditionné en fonction du poids solide.

Autres remarques

Il s′agit de la forme courante du NAD.

Code de la classe de stockage

13 - Non Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

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Certificats d'analyse (COA)

Lot/Batch Number

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Consulter la Bibliothèque de documents

Poly(ADP-ribosyl)ation reactions in the regulation of nuclear functions.

D D'Amours et al.

The Biochemical journal, 342 ( Pt 2), 249-268 (1999-08-24)

Poly(ADP-ribosyl)ation is a post-translational modification of proteins. During this process, molecules of ADP-ribose are added successively on to acceptor proteins to form branched polymers. This modification is transient but very extensive in vivo, as polymer chains can reach more than

Poly(ADP-ribosyl)ation by PARP-1: 'PAR-laying' NAD+ into a nuclear signal.

Mi Young Kim et al.

Genes & development, 19(17), 1951-1967 (2005-09-06)

Poly(ADP-ribose) (PAR) and the PAR polymerases (PARPs) that catalyze its synthesis from donor nicotinamide adenine dinucleotide (NAD+) molecules have received considerable attention in the recent literature. Poly(ADP-ribosyl)ation (PARylation) plays diverse roles in many molecular and cellular processes, including DNA damage

Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging.

Ana P Gomes et al.

Cell, 155(7), 1624-1638 (2013-12-24)

Ever since eukaryotes subsumed the bacterial ancestor of mitochondria, the nuclear and mitochondrial genomes have had to closely coordinate their activities, as each encode different subunits of the oxidative phosphorylation (OXPHOS) system. Mitochondrial dysfunction is a hallmark of aging, but

Benzophenones from an endophytic fungus, Graphiopsis chlorocephala, from Paeonia lactiflora cultivated in the presence of an NAD+-dependent HDAC inhibitor.

Teigo Asai et al.

Organic letters, 15(8), 2058-2061 (2013-04-13)

Graphiopsis chlorocephala was separated from the surface-sterilized healthy leaves of Paeonia lactiflora (Paeoniaceae) and cultivated with nicotinamide (an NAD(+)-dependent HDAC inhibitor). The culture conditions significantly enhanced secondary metabolite production in the fungus and led to the isolation of a structurally

The reaction kinetics of 3-hydroxybenzoate 6-hydroxylase from Rhodococcus jostii RHA1 provide an understanding of the para-hydroxylation enzyme catalytic cycle.

Jeerus Sucharitakul et al.

The Journal of biological chemistry, 288(49), 35210-35221 (2013-10-17)

3-Hydroxybenzoate 6-hydroxylase (3HB6H) from Rhodococcus jostii RHA1 is an NADH-specific flavoprotein monooxygenase that catalyzes the para-hydroxylation of 3-hydroxybenzoate (3HB) to form 2,5-dihydroxybenzoate (2,5-DHB). Based on results from stopped-flow spectrophotometry, the reduced enzyme-3HB complex reacts with oxygen to form a C4a-peroxy

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