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262A-1

Sigma-Aldrich

Granzyme B Rabbit Polyclonal Antibody

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About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Niveau de qualité

100
500

Conjugué

unconjugated

Forme d'anticorps

Ig fraction of antiserum

Type de produit anticorps

primary antibodies

Clone

polyclonal

Description

For In Vitro Diagnostic Use in Select Regions (See Chart)

Forme

buffered aqueous solution

Espèces réactives

human

Conditionnement

vial of 0.1 mL concentrate (262A-14)
vial of 0.5 mL concentrate (262A-15)
bottle of 1.0 mL predilute (262A-17)
vial of 1.0 mL concentrate (262A-16)
bottle of 7.0 mL predilute (262A-18)

Fabricant/nom de marque

Cell Marque™

Technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:10-1:50

Contrôle

ALCL, spleen

Conditions d'expédition

wet ice

Température de stockage

2-8°C

Visualisation

cytoplasmic

Informations sur le gène

human ... GZMB(3002)

Catégories apparentées

Description générale

Granzymes are serine proteases which are stored in specialized lytic granules of cytotoxic T-lymphocytes and in natural killer cells. Anti-granzyme B has been useful in diagnosing natural killer/T-cell lymphoma, as well as anaplastic large cell lymphoma. High percentages of cytotoxic T-cells have been shown to be an unfavorable indicator in Hodgkin disease.

Qualité


IVD
IVD
IVD
RUO

Liaison

Granzyme B Positive Control Slides, Product No. 262S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Forme physique

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Notes préparatoires

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Autres remarques

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Informations légales

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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Consulter la Bibliothèque de documents

J J Oudejans et al.
Blood, 89(4), 1376-1382 (1997-02-15)
Although the results of treatment of Hodgkin's disease (HD) have improved considerably in the last decades, the disease remains fatal in a minority of patients. We have recently shown that numbers of activated cytotoxic T cells (CTLs), present in tumor
J A Kummer et al.
Clinical and experimental immunology, 100(1), 164-172 (1995-04-01)
Cytoplasmic granules from activated natural killer (NK) and cytotoxic T lymphocytes (CTL) contain a pore-forming protein, perforin, and several homologous serine proteinases called granzymes. Expression of these proteins correlates with the cytolytic potential of cytotoxic lymphocytes. Using a panel of
Naoko Kato et al.
The American Journal of dermatopathology, 25(2), 142-147 (2003-03-26)
A neutrophil-rich anaplastic large cell lymphoma (ALCL) presented in the skin of a 47-year-old Japanese woman. The solitary cutaneous lesion was an eroded, 10-mm, dome-shaped nodule involving the skin of her left upper arm. Histologically, it showed a proliferation of
J J Oudejans et al.
The American journal of pathology, 148(1), 233-240 (1996-01-01)
Reed-Sternberg (RS) and Hodgkin's (H) cells are considered to be the neoplastic cells in Hodgkin's disease. Although most data suggest a lymphoid origin, the nature of these cells still remains the subject of considerable controversy. Recently, monoclonal antibodies became available
Jie Liu et al.
The Journal of dermatology, 30(10), 735-741 (2003-12-20)
Nasal natural killer (NK)/T cell lymphoma is an Epstein-Barr virus (EBV) associated lymphoma that arises in the nasal area and aggressively invades surrounding tissues. Our patient was a 48-year-old male who had had nasal obstruction and nasal discharge for 2

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