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Y0000635

Modafinil

European Pharmacopoeia (EP) Reference Standard

Synonyme(s) :

2-[(Diphenylmethyl)sulfinyl]­acetamide

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About This Item

Formule empirique (notation de Hill):
C15H15NO2S
Numéro CAS:
68693-11-8
Poids moléculaire :
273.35
Numéro MDL:
MFCD00868082
Code UNSPSC :
41116107
ID de substance PubChem :
329831065
Nomenclature NACRES :
NA.24

Qualité

pharmaceutical primary standard

Famille d'API

modafinil

Fabricant/nom de marque

EDQM

Application(s)

pharmaceutical (small molecule)

Format

neat

Chaîne SMILES 

NC(=O)CS(=O)C(c1ccccc1)c2ccccc2

InChI

1S/C15H15NO2S/c16-14(17)11-19(18)15(12-7-3-1-4-8-12)13-9-5-2-6-10-13/h1-10,15H,11H2,(H2,16,17)

Clé InChI

YFGHCGITMMYXAQ-UHFFFAOYSA-N

Informations sur le gène

human ... SLC6A3(6531)

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Description générale

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Modafinil EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Actions biochimiques/physiologiques

Modafinil is a central nervous system vigilance promoting agent, which posseses neuroprotective properties.

Conditionnement

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Autres remarques

Sales restrictions may apply.

Pictogrammes

Health hazardExclamation mark
GHS08,GHS07

Mention d'avertissement

Warning

Mentions de danger

H302,H361d

Classification des risques

Acute Tox. 4 Oral - Repr. 2

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Certificats d'analyse (COA)

Lot/Batch Number

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Consulter la Bibliothèque de documents

Mariana Raineri et al.
PloS one, 7(10), e46599-e46599 (2012-10-12)
Methamphetamine is a drug of abuse that can cause neurotoxic damage in humans and animals. Modafinil, a wake-promoting compound approved for the treatment of sleeping disorders, is being prescribed off label for the treatment of methamphetamine dependence. The aim of
Trends in on-label and off-label modafinil use in a nationally representative sample.
Renée A Peñaloza et al.
JAMA internal medicine, 173(8), 704-706 (2013-04-05)
Derek Dunn et al.
Chemical biology & drug design, 81(3), 433-435 (2012-12-05)
Utilizing atypical wake-promoting agent modafinil (inactive in both rH(3) and hH(3) binding assays) as a launching pad, a series of sulfinyl- and sulfone-derived H(3) receptor inverse agonists were developed. Brain-permeable compound 27, a potent member of the series displayed excellent
Arterial hypertension and resistance to antihypertensive treatment: a new adverse drug reaction with modafinil.
Jacques Amar et al.
Therapie, 68(1), 53-54 (2013-03-15)
Jordy van Enkhuizen et al.
Psychopharmacology, 225(3), 661-674 (2012-09-05)
The Iowa Gambling Task (IGT) can be used to quantify impulsive and risky choice behaviors in psychiatric patients, e.g., bipolar disorder (BD) sufferers. Although developing treatments for these behaviors is important, few predictive animal models exist. Inhibition of the dopamine
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