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Principaux documents

O0146000

Olsalazine sodium

European Pharmacopoeia (EP) Reference Standard

Synonyme(s) :

4,4′-Dihydroxyazobenzene-3,3′-dicarboxylic acid disodium salt, 5,5′-Azobis(salicylic acid, sodium salt), Mordant Yellow 5

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About This Item

Formule empirique (notation de Hill) :
C14H8N2Na2O6
Numéro CAS:
6054-98-4
Poids moléculaire :
346.20
Code UNSPSC :
41116107
Nomenclature NACRES :
NA.24

Qualité

pharmaceutical primary standard

Famille d'API

olsalazine

Fabricant/nom de marque

EDQM

Application(s)

pharmaceutical (small molecule)

Format

neat

Température de stockage

2-8°C

Chaîne SMILES 

[Na+].[Na+].N(\N=C2/C=C(C(=O)C=C/2)C(=O)[O-])c1cc(c(cc1)O)C(=O)[O-]

InChI

1S/C14H10N2O6.2Na/c17-11-3-1-7(5-9(11)13(19)20)15-16-8-2-4-12(18)10(6-8)14(21)22;;/h1-6,15,17H,(H,19,20)(H,21,22);;/q;2*+1/p-2/b16-8-;;

Clé InChI

QQWFSVYVHLECFP-XBPUGJBTSA-L

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Description générale

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Olsalazine sodium EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Conditionnement

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Autres remarques

Sales restrictions may apply.

Produit(s) apparenté(s)

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Description
Tarif

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Consulter la Bibliothèque de documents

Xinming Li et al.
Journal of the American Chemical Society, 132(50), 17707-17709 (2010-12-03)
Conjugation of tripeptide derivatives with olsalazine, a clinically used anti-inflammatory prodrug, yields small molecules that self-assemble in water to form supramolecular hydrogels that undergo a gel-to-sol phase transition upon reduction, resulting in the controlled release of 5-aminosalicylic acid as the
Kersti Oselin et al.
Drug metabolism and disposition: the biological fate of chemicals, 35(9), 1452-1454 (2007-06-08)
Thiopurine S-methyltransferase (TPMT) is a biotransformation phase II enzyme responsible for the metabolic inactivation of thiopurine drugs. The present study was carried out to investigate the inhibitory potential of 15 nonsteroidal anti-inflammatory drugs (NSAIDs) on human TPMT activity in vitro.
David T Rubin et al.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 4(11), 1346-1350 (2006-10-25)
Aminosalicylates have been suggested as chemopreventive agents for colorectal cancer (CRC) in ulcerative colitis (UC). We studied the effect of aminosalicylate use on dysplasia and CRC risk in chronic UC. UC patients with dysplasia or CRC were matched with controls
K W Schroeder
Scandinavian journal of gastroenterology. Supplement, (236)(236), 42-47 (2002-11-01)
Sulfasalazine, consisting of 5-aminosalicylic acid bound to sulfapyridine by a diazo bond, was first used for treatment of ulcerative colitis in the early 1940s and later found effective in placebo-controlled trials for acute disease and for long-term maintenance of remission.
U Knoll et al.
Journal of veterinary pharmacology and therapeutics, 25(2), 135-143 (2002-05-10)
Olsalazine sodium (Dipentum*) has been used therapeutically against inflammatory bowel disease in human medicine as an alternative to sulphasalazine over the past 20 years. Bacteria in the colon split this prodrug into two molecules of the locally effective 5-aminosalicylic acid
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