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N0020000

Nabumetone

European Pharmacopoeia (EP) Reference Standard

Synonyme(s) :

4-(6-Methoxy-2-naphthyl)-2-butanone

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About This Item

Formule empirique (notation de Hill):
C15H16O2
Numéro CAS:
42924-53-8
Poids moléculaire :
228.29
Numéro MDL:
MFCD00079518
Code UNSPSC :
41116107
ID de substance PubChem :
329818390
Nomenclature NACRES :
NA.24

Qualité

pharmaceutical primary standard

Famille d'API

nabumetone

Fabricant/nom de marque

EDQM

Application(s)

pharmaceutical (small molecule)

Format

neat

Chaîne SMILES 

COc1ccc2cc(CCC(C)=O)ccc2c1

InChI

1S/C15H16O2/c1-11(16)3-4-12-5-6-14-10-15(17-2)8-7-13(14)9-12/h5-10H,3-4H2,1-2H3

Clé InChI

BLXXJMDCKKHMKV-UHFFFAOYSA-N

Informations sur le gène

human ... PTGS2(5743)

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Catégories apparentées

Description générale

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Nabumetone EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Actions biochimiques/physiologiques

Nonselective non-steroidal anti-inflammatory drug (NSAID)

Conditionnement

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Autres remarques

Sales restrictions may apply.

Produit(s) apparenté(s)

Réf. du produit
Description
Tarif

N0020020

Nabumetone impurity D, European Pharmacopoeia (EP) Reference Standard

N0020030

Nabumetone impurity F, European Pharmacopoeia (EP) Reference Standard

1449518

Nabumetone, United States Pharmacopeia (USP) Reference Standard

1449530

Nabumetone Related Compound A, United States Pharmacopeia (USP) Reference Standard

08137

2-(6-Methoxynaphthalen-2-yl)acetic acid, pharmaceutical impurity standard

BP358

Nabumetone, British Pharmacopoeia (BP) Reference Standard

BP851

Nabumetone impurity D, British Pharmacopoeia (BP) Reference Standard

PHR3056

Nabumetone, pharmaceutical secondary standard, certified reference material

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Certificats d'analyse (COA)

Lot/Batch Number

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Consulter la Bibliothèque de documents

Solubility of triamcinolone acetonide and other anti-inflammatory drugs in silicone oil: implications for Therapeutic Efficacy.
José Carlos Pastor et al.
Retina (Philadelphia, Pa.), 28(9), 1247-1250 (2008-07-17)
Michael Crothers et al.
International journal of pharmaceutics, 358(1-2), 303-306 (2008-04-18)
The solubilisation of two poorly soluble drugs, furosemide and nabumetone, in micellar solutions of diblock copolymers of ethylene oxide and styrene oxide has been studied at 25 and 37 degrees C and solubilisation capacities compared with published values for griseofulvin
Kaori Matsumoto et al.
Biological & pharmaceutical bulletin, 34(5), 734-739 (2011-05-03)
The cytochrome P450 (CYP) isoforms that catalyze the oxidation metabolism of 6-methoxy-2-napthylacetic acid (6-MNA), an active metabolite of nabumetone, were studied in rats and humans. Using an extractive reversed-phase HPLC assay with fluorescence detection, monophasic Michaelis-Menten kinetics was obtained for
Jinhyun Kim et al.
Clinical therapeutics, 31(12), 2860-2872 (2010-01-30)
S-adenosylmethionine (SAMe) has antiinflammatory and analgesic effects and has been reported to ameliorate the pain and dysfunction of osteoarthritis (OA). The metabolism of SAMe can be affected by geographic or ethnic factors. However, its efficacy and tolerability versus NSAIDs have
Miia Turpeinen et al.
Drug metabolism and disposition: the biological fate of chemicals, 37(5), 1017-1024 (2009-02-11)
Nabumetone, a widely used nonsteroidal anti-inflammatory drug, requires biotransformation into 6-methoxy-2-naphthylacetic acid (6-MNA), a close structural analog to naproxen, to achieve its analgesic and anti-inflammatory effects. Despite its wide use, the enzymes involved in metabolism have not been identified. In
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