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H0800000

Homatropine hydrobromide

European Pharmacopoeia (EP) Reference Standard

Synonyme(s) :

DL-Homatropine hydrobromide, DL-endo-α-Hydroxybenzeneacetic acid 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester hydrobromide, Tropine mandelate hydrobromide

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About This Item

Formule empirique (notation de Hill):
C16H21NO3 · HBr
Numéro CAS:
51-56-9
Poids moléculaire :
356.25
Numéro MDL:
MFCD00012676
Code UNSPSC :
41116107
ID de substance PubChem :
329815135
Nomenclature NACRES :
NA.24

Qualité

pharmaceutical primary standard

Famille d'API

homatropine

Fabricant/nom de marque

EDQM

Pf

214-217 °C (lit.)

Application(s)

pharmaceutical (small molecule)

Format

neat

Température de stockage

2-8°C

Chaîne SMILES 

Br.CN1C2CCC1CC(C2)OC(=O)C(O)c3ccccc3

InChI

1S/C16H21NO3.BrH/c1-17-12-7-8-13(17)10-14(9-12)20-16(19)15(18)11-5-3-2-4-6-11;/h2-6,12-15,18H,7-10H2,1H3;1H

Clé InChI

DWSGTFTVBLXELC-UHFFFAOYSA-N

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Catégories apparentées

Description générale

Homatropine hydrobromide is an anticholinergic agent and is commonly used as a mydriatic and cycloplegic drug in ophthalmology.
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

This European Pharmacopoeia reference standard is intended for use only as specifically prescribed in the European Pharmacopoeia.

Conditionnement

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Autres remarques

Sales restrictions may apply.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Lot/Batch Number

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Amol Tamhane et al.
Ophthalmology, 112(11), 1963-1969 (2005-10-04)
To evaluate the role of amniotic membrane transplantation (AMT) in acute ocular burns. Prospective, randomized, controlled clinical trial. Patients with grade II to IV ocular burns within 3 weeks of injury were recruited. Thirty-seven patients, 7 of whom had bilateral
Elizabeth Hanno et al.
Optometry (St. Louis, Mo.), 80(2), 70-75 (2009-02-04)
Bilateral, recurrent, or chronic anterior uveitis requires a diagnostic evaluation to rule out any systemic cause. An understanding of the possible etiologies and their diagnostic criteria is needed to manage these patients. Treating any systemic cause can decrease the recurrent
N George et al.
Autonomic & autacoid pharmacology, 30(3), 173-177 (2010-01-21)
This study investigated whether four anticholinergics which are not clinically used for relaxing the urinary bladder detrusor muscle inhibit the contraction of isolated caprine (goat) detrusor muscle: cyclopentolate (100 nm), homatropine (5 microm), ipratropium (500 nm) and valethamate (1 microm).
Sean M Bryant et al.
Journal of medical toxicology : official journal of the American College of Medical Toxicology, 2(4), 156-159 (2007-12-12)
Most hospitals lack a sufficient supply of atropine to treat, simultaneously, patients poisoned with multiple organophosphorous compound (OC) or nerve agent. The presence of a ubiquitous alternate antidote would prove useful if mass poisoning occurred. Our objective was to evaluate
Colin C K Chan et al.
Clinical & experimental ophthalmology, 33(3), 296-297 (2005-06-04)
A case is reported of formation of a dense intraocular membrane following combined phacoemulsification-trabeculectomy surgery. The membrane might have originated from a loose piece of pigment epithelium or might have resulted from dense pigment deposition on a postoperative pupillary membrane.
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