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89640

Sigma-Aldrich

Toluidine Blue

8.74% (ZN (THEORY)), for microscopy (Hist., Vit.)

Synonyme(s) :

Tolonium chloride; Basic Blue 17

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About This Item

Formule empirique (notation de Hill):
C15H16ClN3S · 0.5ZnCl2
Numéro CAS:
6586-04-5
Poids moléculaire :
373.97
Numéro C.I. (Colour Index):
52040
Numéro Beilstein :
4068052
Numéro MDL:
MFCD03548293
Code UNSPSC :
12171500
ID de substance PubChem :
329769757
Nomenclature NACRES :
MA.02

Qualité

for microscopy (Hist., Vit.)

Niveau de qualité

200

Pureté

8.74% (ZN (THEORY))

Forme

powder or crystals

Couleur

green to very dark green

Solubilité

methanol: 0.01 g/10 mL, blue to very deep blue

εmax

≥800 at 621-636 nm in water

Application(s)

diagnostic assay manufacturing
hematology
histology

Température de stockage

room temp

Chaîne SMILES 

[Cl-].[Cl-].Cl[Zn]Cl.Cc1cc2N=C3C=CC(\C=C3Sc2cc1N)=[N+](\C)C.Cc4cc5N=C6C=CC(\C=C6Sc5cc4N)=[N+](\C)C

InChI

1S/2C15H15N3S.4ClH.Zn/c2*1-9-6-13-15(8-11(9)16)19-14-7-10(18(2)3)4-5-12(14)17-13;;;;;/h2*4-8,16H,1-3H3;4*1H;/q;;;;;;+2/p-2

Clé InChI

DAQXTSXITPUGRG-UHFFFAOYSA-L

Catégories apparentées

Description générale

Toluidine blue (C.l. 52040) is a diaminothiazine dye.It is also known as TBO, tolonium chloride, and toluidine blue O.

Application

Toluidine Blue is suitable for use in the following applications:
  1. to demonstrate amyloid; DNA in plant material, mast cells, Nissl substance, nuclei, and sulfatides
  2. in metachromatic staining of sulfated mucins and related materials
  3. as staining agent to identify the development and accumulation of the cartilage matrix, proteoglycans for isolation and culture of mesenchymal stem cells from mouse compact bone.
  4. staining of mucins in water-miscible resins and of nucleic acids in epoxy resins(1)

Actions biochimiques/physiologiques

Toluidine Blue is a basic thiazine metachromatic dye, which is used for selectively staining acidic tissue components such as carboxylates, sulfates, and phosphate radicals.It is found to have an affinity for nucleic acids and therefore binds to the nuclear material of tissues with a high DNA and RNA content.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

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Certificats d'analyse (COA)

Lot/Batch Number
BCCK0876
BCCL0360
BCCH1582
BCCD9721
BCBZ9485

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Ulrike Kettenberger et al.
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Yamuhanmode Alike et al.
Neural regeneration research, 14(12), 2173-2182 (2019-08-10)
The intermingling of regenerated nerve fibers inside nerve grafts is the main reason for mismatched nerve fibers. This is one of the key factors affecting limb function recovery after nerve injury. Previous research has shown that the accuracy of axon
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The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology, 30(8), 732-744 (2019-08-17)
Xylopic acid (XA) has been reported to exhibit analgesic activity, alleviate neuropathic pain in rodents, and demonstrate anti-inflammatory effects. Intrarectal challenge of rats with acetic acid induces colitis that bears resemblance in terms of its pathogenesis, histopathology, and inflammatory profile
Alessio Papini et al.
Plant science : an international journal of experimental plant biology, 286, 37-48 (2019-07-14)
In this work, a non-metallicolous and a metallicolous population of S. paradoxa were exposed to copper excess and fungal elicitation, and investigated for phytohormone production and cytological alterations. Under the stress applied separately and in combination, S. paradoxa plants varied
Xiaoli Guo et al.
PLoS pathogens, 13(2), e1006142-e1006142 (2017-02-06)
Stem cell pools in the SAM (shoot apical meristem), RAM (root apical meristem) and vascular procambium/cambium are regulated by CLE-receptor kinase-WOX signaling modules. Previous data showed that cyst nematode CLE-like effector proteins delivered into host cells through a stylet, act
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