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34091

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Flubendazol

VETRANAL®, analytical standard

Synonyme(s) :

Flumoxanal, Methyl [5-(4-fluorobenzoyl)-1H-benzimidazol-2-yl]carbamate

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About This Item

Formule empirique (notation de Hill):
C16H12FN3O3
Numéro CAS:
31430-15-6
Poids moléculaire :
313.28
Numéro CE :
250-624-4
Numéro MDL:
MFCD00871999
Code UNSPSC :
41116107
ID de substance PubChem :
329754807
Nomenclature NACRES :
NA.24

Qualité

analytical standard

Niveau de qualité

100

Gamme de produits

VETRANAL®

Durée de conservation

limited shelf life, expiry date on the label

Technique(s)

HPLC: suitable
gas chromatography (GC): suitable

Application(s)

forensics and toxicology
pharmaceutical (small molecule)

Format

neat

Chaîne SMILES 

COC(=O)Nc1nc2cc(ccc2[nH]1)C(=O)c3ccc(F)cc3

InChI

1S/C16H12FN3O3/c1-23-16(22)20-15-18-12-7-4-10(8-13(12)19-15)14(21)9-2-5-11(17)6-3-9/h2-8H,1H3,(H2,18,19,20,22)

Clé InChI

CPEUVMUXAHMANV-UHFFFAOYSA-N

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Catégories apparentées

Description générale

Flubendazol is a broad spectrum anthelmintic, which belongs to the class of compounds known as benzimidazoles. It can be widely used in veterinary and human medicine. It mainly finds applications in deworming poultry, swine, dogs and cats.
Flubendazol is an injectable benzimidazole drug; though it is poorly absorbed it is quite effective in the treatment of trycocephalus, ascaris and oxyuriasis in both children and adults.

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
VETRANAL® analytical standard can be used in the liquid chromatography coupled to mass spectrometry (LC-MS/MS) procedure, performed for the analysis of macrocyclic lactones in milk.

Informations légales

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 2

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

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Certificats d'analyse (COA)

Lot/Batch Number
BCCD3951
BCBW0774
SZBF099XV
SZBB157XV
SZB9216XV

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Sigma-Aldrich

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Gabriel Rübensam et al.
Analytica chimica acta, 705(1-2), 24-29 (2011-10-04)
In this work a method is proposed and demonstrated for the analysis of the macrocyclic lactones abamectin, doramectin, eprinomectin, ivermectin and moxidectin in bovine milk by liquid chromatography coupled to mass spectrometry (LC-MS/MS) and liquid chromatography with fluorescence detection (LC-FL).
Paul A Spagnuolo et al.
Blood, 115(23), 4824-4833 (2010-03-30)
On-patent and off-patent drugs with previously unrecognized anticancer activity could be rapidly repurposed for this new indication given their prior toxicity testing. To identify such compounds, we conducted chemical screens and identified the antihelmintic flubendazole. Flubendazole induced cell death in
H Bártíková et al.
Journal of veterinary pharmacology and therapeutics, 33(1), 56-62 (2010-05-07)
The aim of this project was to study the influence of haemonchosis, a common parasitic infection of small ruminants caused by Haemonchus contortus, on the activity of biotransformation enzymes and on in vitro flubendazole (FLU) biotransformation in liver and small
Integrated pharmacological assessment of flubendazole potential for use in sheep: disposition kinetics, liver metabolism and parasite diffusion ability
Moreno.L, et al.
Journal of Veterinary Pharmacology and Therapeutics, 27, 299-308 (2004)
Laura Ceballos et al.
Chemotherapy, 56(5), 386-392 (2010-10-16)
Cystic echinococcosis (CE) is an important public health problem worldwide. Flubendazole, administered in tablets, has shown poor in vivo efficacy against CE in humans. However, flubendazole prepared as a solution caused a marked reduction in hydatid cysts developed in mice.
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