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33818

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5-Hydroxythiabendazole

PESTANAL®, analytical standard

Synonyme(s) :

2-(4-Thiazolyl)-5-benzimidazolol, 5-Hydroxy-2-(4-thiazolyl)benzimidazole

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About This Item

Formule empirique (notation de Hill):
C10H7N3OS
Numéro CAS:
948-71-0
Poids moléculaire :
217.25
Numéro MDL:
MFCD00152219
Code UNSPSC :
41116107
ID de substance PubChem :
329754660
Nomenclature NACRES :
NA.24

Qualité

analytical standard

Niveau de qualité

100

Gamme de produits

PESTANAL®

Durée de conservation

limited shelf life, expiry date on the label

Technique(s)

HPLC: suitable
gas chromatography (GC): suitable

Application(s)

agriculture
environmental
forensics and toxicology
veterinary

Format

neat

Chaîne SMILES 

Oc1ccc2[nH]c(nc2c1)-c3cscn3

InChI

1S/C10H7N3OS/c14-6-1-2-7-8(3-6)13-10(12-7)9-4-15-5-11-9/h1-5,14H,(H,12,13)

Clé InChI

VNENJHUOPQAPAT-UHFFFAOYSA-N

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Description générale

5-Hydroxythiabendazole present in excreta, eggs, edible tissues and milk is found to be the major metabolite of thiabendazole, an active ingredient in fungicidal preparations effective for plants. It can also be used as an anthelmintic drug, which is applicable both for humans and animals.

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Thiabendazole and its metabolite 5-hydroxythiabendazole can undergo specific binding with monoclonal antibodies and can further undergo immobilization on agarose gels, which can find applications in immunoaffinity chromatography.

Informations légales

PESTANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictogrammes

Exclamation markEnvironment
GHS07,GHS09

Mention d'avertissement

Warning

Mentions de danger

H302,H400

Conseils de prudence

P273 - P301 + P312 + P330

Classification des risques

Acute Tox. 4 Oral - Aquatic Acute 1

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

dust mask type N95 (US), Eyeshields, Gloves

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Certificats d'analyse (COA)

Lot/Batch Number
BCCH9374
BCCH0371
BCCG0673
BCCF0006
BCCD2329

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Immobilisation of thiabendazole specific antibodies on an agarose matrix for application in immunoaffinity chromatography
Horne E, et al.
Analyst, 124, 87-90 (1999)
A Cannavan et al.
Journal of chromatography. B, Biomedical sciences and applications, 718(1), 103-113 (1998-12-01)
A novel method is presented for the determination of thiabendazole and 5-hydroxythiabendazole in animal tissues. Samples are homogenised in buffer at pH=7.0, extracted with ethyl acetate and cleaned up using CN solid-phase extraction columns. Thiabendazole and 5-hydroxythiabendazole are separated chromatographically
S S Tai et al.
Journal - Association of Official Analytical Chemists, 73(3), 368-373 (1990-05-01)
The liquid chromatographic determination previously developed for benzimidazoles in cattle liver has been slightly modified and applied to the determination of 4 benzimidazoles in milk. Recoveries of fenbendazole (FBZ), oxfendazole (OFZ), and thiabendazole (TBZ) from milk fortified at the 10
Metabolism of thiabendazole in laying hen and lactating goats
Chukwudebe.CA, et al.
Journal of Agricultural and Food Chemistry, 42, 2964-2969 (1994)
D Kerboeuf et al.
Veterinary parasitology, 93(1), 47-55 (2000-10-12)
Four groups of three lambs per group were experimentally infected with Cooperia curticei susceptible (two groups) or resistant (two groups) to benzimidazoles, and distributions of adult worms in the small intestine were studied. For each Cooperia isolate, one group was
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