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31493

Sigma-Aldrich

Salicylate de sodium

puriss. p.a., reag. Ph. Eur., 99.5-101.0% (calc. to the dried substance)

Synonyme(s) :

2-Hydroxybenzoate de sodium, Acide 2-hydroxybenzoïque sodium salt, Acide salicylique sodium salt

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About This Item

Formule linéaire :
HOC6H4COONa
Numéro CAS:
54-21-7
Poids moléculaire :
160.10
Numéro Beilstein :
3732792
Numéro CE :
200-198-0
Numéro MDL:
MFCD00002440
Code UNSPSC :
12352100
ID de substance PubChem :
57648580
Nomenclature NACRES :
NA.21

Agence

USP/NF
reag. Ph. Eur.

Niveau de qualité

100

Qualité

puriss. p.a.

Pureté

99.5-101.0% (calc. to the dried substance)

Impuretés

acidic reac. impurities, complies
 sulfite or thiosulfate, complies
≤0.001% heavy metals (as Pb)

Perte

≤0.3% loss on drying, 105 °C

Pf

>300 °C (lit.)

Traces d'anions

chloride (Cl-): ≤20 mg/kg
sulfate (SO42-): ≤500 mg/kg

Traces de cations

Fe: ≤10 mg/kg

Adéquation

in accordance for appearance of solution

Chaîne SMILES 

[Na+].Oc1ccccc1C([O-])=O

InChI

1S/C7H6O3.Na/c8-6-4-2-1-3-5(6)7(9)10;/h1-4,8H,(H,9,10);/q;+1/p-1

Clé InChI

ABBQHOQBGMUPJH-UHFFFAOYSA-M

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Description générale

Sodium salicylate can be prepared from the reaction of salicylic acid and ammonia. It exhibits fluorescence at higher concentrations and effectively absorbs β-particles. Due to these properties, it has been employed as fluor for the radioactivity detection in various gels.

Application

Sodium salicylate may be used as phenolic reagent in salicylate method for the determination of ammonia. It may be employed as a hydrotropic agent to study the release of anticancer drug camptothecin (CPT) from the mixed micelles [composed of Pluronic P105 (P105) and D-α-tocopheryl polyethylene glycol 1000 succinate (TPGS)].

Pictogrammes

Health hazardExclamation mark
GHS08,GHS07

Mention d'avertissement

Warning

Mentions de danger

H302,H319,H361d

Classification des risques

Acute Tox. 4 Oral - Eye Irrit. 2 - Repr. 2

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

208.9 °F - Pensky-Martens closed cup

Point d'éclair (°C)

98.3 °C - Pensky-Martens closed cup

Équipement de protection individuelle

dust mask type N95 (US), Eyeshields, Gloves

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Certificats d'analyse (COA)

Lot/Batch Number
STBL4722
STBL4097
STBL1811
STBK8935
STBK7750

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Sigma-Aldrich

8.18731

Salicylic acid

Yan Gao et al.
Colloids and surfaces. B, Biointerfaces, 64(2), 194-199 (2008-03-08)
To increase the solubility and cytotoxicity of poorly soluble anticancer drug camptothecin (CPT), mixed micelles made of Pluronic P105 (P105) and d-alpha-tocopheryl polyethylene glycol 1,000 succinate (TPGS) were prepared. The interaction of Pluronic and TPGS was studied and critical micelle
Ammonia determination based on indophenol formation with sodium salicylate.
Verdouw H, et al.
Water Research, 12(6), 399-402 (1978)
Fluorographic detection of radioactivity in polyacrylamide gels with the water-soluble fluor, sodium salicylate.
J P Chamberlain
Analytical biochemistry, 98(1), 132-135 (1979-09-15)
Kui Wang et al.
Journal of medicinal chemistry, 52(20), 6402-6412 (2009-10-16)
Viologens are showing an increasing number of scientific and technical applications in addition to their use as herbicides. However, their high toxicity poses considerable risks to human health, society, and the environment. In this context, we propose a new therapeutic
Rainer Amann et al.
European journal of pharmacology, 447(1), 1-9 (2002-07-11)
Aspirin (acetylsalicylic acid) is one of the most widely used drugs worldwide. It acetylates cyclooxygenases thereby irreversibly blocking the conversion of arachidonic acid to prostanoids. Biotransformation of aspirin yields salicylate, a compound that possesses similar anti-inflammatory potency as aspirin but
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