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Glycidamide

analytical standard

Synonyme(s) :

2,3-Epoxypropanamide, Oxiranecarboxamide

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About This Item

Formule empirique (notation de Hill):
C3H5NO2
Numéro CAS:
5694-00-8
Poids moléculaire :
87.08
Numéro Beilstein :
227 163 2
Numéro CE :
227-163-2
Numéro MDL:
MFCD00468053
Code UNSPSC :
41116107
ID de substance PubChem :
329747975
Nomenclature NACRES :
NA.24

Qualité

analytical standard

Niveau de qualité

100

Pureté

≥95% (qNMR)

Durée de conservation

limited shelf life, expiry date on the label

Application(s)

environmental

Format

neat

Température de stockage

2-8°C

Chaîne SMILES 

NC(=O)C1CO1

InChI

1S/C3H5NO2/c4-3(5)2-1-6-2/h2H,1H2,(H2,4,5)

Clé InChI

FMAZQSYXRGRESX-UHFFFAOYSA-N

Catégories apparentées

Description générale

Glycidamide, an active epoxide metabolite of acrylamide with potential biological activity, can be generated in vivo. Its mutagenic and genotoxic nature is well-known.

Application

Glycidamide may be used as an analytical standard for the determination of the analyte in human and animal biological samples by various chromatography techniques.

Autres remarques

In the summer of 2008 research scientists at the Technical University of Munich besides acrylamide detected glycidamide in potato crisps. Glycidamide is a metabolite of acrylamide.

Pictogrammes

Health hazardExclamation mark
GHS08,GHS07

Mention d'avertissement

Danger

Classification des risques

Acute Tox. 4 Oral - Carc. 1B - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

Organes cibles

Respiratory system

Code de la classe de stockage

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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Certificats d'analyse (COA)

Lot/Batch Number
BCCK2598
BCCC1244
BCCC1105
BCCB2285
BCBW5033

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Glycidol 96%

Sigma-Aldrich

G5809

Glycidol

Talita Duarte-Salles et al.
Environmental health perspectives, 121(3), 374-379 (2012-12-04)
Acrylamide has shown developmental and reproductive toxicity in animals, as well as neurotoxic effects in humans with occupational exposures. Because it is widespread in food and can pass through the human placenta, concerns have been raised about potential developmental effects
Nico Watzek et al.
Chemical research in toxicology, 25(2), 381-390 (2012-01-04)
Acrylamide (AA) is formed during the heating of food and is classified as a genotoxic carcinogen. The margin of exposure (MOE), representing the distance between the bench mark dose associated with 10% tumor incidence in rats and the estimated average
Hitesh V Motwani et al.
Scientific reports, 7(1), 17560-17560 (2017-12-16)
When employing metabolism studies of genotoxic compounds/metabolites and cancer tests for risk estimation, low exposure doses in humans are roughly extrapolated from high exposure doses in animals. An improvement is to measure the in vivo dose, i.e. area under concentration-time
Hitesh V Motwani et al.
Journal of chromatography. A, 1218(28), 4389-4394 (2011-06-10)
Glycidamide (GA) is the epoxy metabolite of acrylamide (AA). A sensitive analytical method for quantitative measurement of GA from in vitro metabolism studies is useful in several contexts, e.g. in studies of enzyme kinetics in different species and factors influencing
Marie Pedersen et al.
Environmental health perspectives, 120(12), 1739-1745 (2012-10-25)
Acrylamide is a common dietary exposure that crosses the human placenta. It is classified as a probable human carcinogen, and developmental toxicity has been observed in rodents. We examined the associations between prenatal exposure to acrylamide and birth outcomes in
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