SCT082
BioTracker Red MAO-A Live Cell Dye
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About This Item
Code UNSPSC :
12352207
Nomenclature NACRES :
NA.47
Produits recommandés
Pureté
≥98% (HPLC)
Forme
lyophilized
Poids mol.
calculated mol wt 266.38
Conditionnement
pkg of 1 mg
Fabricant/nom de marque
Millipore
Conditions de stockage
desiccated
protect from light
Technique(s)
cell based assay: suitable
Couleur
yellow
Méthode de détection
fluorometric
Conditions d'expédition
ambient
Température de stockage
−20°C
Description générale
Monoamine oxidases (MAOs) are important enzymes that catalyze the transformation of various neurotransmitters including serotonin, dopamine, and phenethylamine. They have two functionally distinct but structurally similar isoforms (MAO-A and MAO-B). The ability to differentiate the isoforms by using fluorescence detection/imaging technology is biologically relevant, but challenging with currently available chemical tools.
BioTracker Red MAO-A Live Cell Dye is a specific two-photon fluorogenic probe for detecting and visualizing MAO-A activity. This probe may be used to detect MAO-A enzymatic activities in various biological samples, including live mammalian cells, mouse and human tissues by using two-photon fluorescence microscopy with minimal cytotoxicity.
Reference:
1. Fang, H., Zhang, H., Li, L., Ni, Y., Shi, R., Li, Z., ... & Huang, W. (2020). Rational Design of a Two?Photon Fluorogenic Probe for Visualizing Monoamine Oxidase A Activity in Human Glioma Tissues. Angewandte Chemie, 132(19), 7606-7611.
BioTracker Red MAO-A Live Cell Dye is a specific two-photon fluorogenic probe for detecting and visualizing MAO-A activity. This probe may be used to detect MAO-A enzymatic activities in various biological samples, including live mammalian cells, mouse and human tissues by using two-photon fluorescence microscopy with minimal cytotoxicity.
Reference:
1. Fang, H., Zhang, H., Li, L., Ni, Y., Shi, R., Li, Z., ... & Huang, W. (2020). Rational Design of a Two?Photon Fluorogenic Probe for Visualizing Monoamine Oxidase A Activity in Human Glioma Tissues. Angewandte Chemie, 132(19), 7606-7611.
Application
Purity ≥ 98% confirmed by HPLC. Identification confirmed by HNMR, LC-MS, and elemental analysis.
Caractéristiques et avantages
Specific two-photon fluorogenic probe for detecting and visualizing MAO-A activity in live cells, mouse and human tissues.
Forme physique
Lyophilized. Yellow solid.
Stockage et stabilité
Store at -20°C, desiccate and protect from light
Note: Centrifuge vial briefly to collect contents at bottom of vial before opening
Note: Centrifuge vial briefly to collect contents at bottom of vial before opening
Autres remarques
Live cell fluorescent imaging
Clause de non-responsabilité
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Code de la classe de stockage
11 - Combustible Solids
Classe de danger pour l'eau (WGK)
WGK 3
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Certificats d'analyse (COA)
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Haixiao Fang et al.
Angewandte Chemie (International ed. in English), 59(19), 7536-7541 (2020-02-23)
Monoamine oxidases have two functionally distinct but structurally similar isoforms (MAO-A and MAO-B). The ability to differentiate them by using fluorescence detection/imaging technology is of significant biological relevance, but highly challenging with available chemical tools. Herein, we report the first
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