PC165L
Anti-Opioid μ Receptor (384-398) Rabbit pAb
lyophilized, Calbiochem®
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About This Item
Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41
Source biologique
rabbit
Niveau de qualité
Forme d'anticorps
serum
Type de produit anticorps
primary antibodies
Clone
polyclonal
Forme
lyophilized
Ne contient pas
preservative
Espèces réactives
rat
Fabricant/nom de marque
Calbiochem®
Conditions de stockage
OK to freeze
Isotype
IgG
Conditions d'expédition
ambient
Température de stockage
−20°C
Modification post-traductionnelle de la cible
unmodified
Informations sur le gène
rat ... Oprm1(25601)
Description générale
Rabbit polyclonal antibody supplied as lyophilized, undiluted serum. Recognizes the ~44-45 kDa opioid µ receptor protein.
Recognizes the ~44-45 kDa opiod μ receptor in caudate putamen and the dorsal horn of the spinal cord.
This Anti-Opioid µ Receptor (384-398) Rabbit pAb is validated for use in Frozen Sections, Immunoblotting, IF, IP for the detection of Opioid µ Receptor (384-398).
Immunogène
Rat
a synthetic peptide corresponding to amino acids 384-398 of rat opioid µ receptor
Application
Frozen Sections (1:500-1:1000, Cy3 technique; 1:3000-1:6000, HRP)
Immunoblotting (1:2000-1:2500; see application references)
Immunofluorescence (1:100-1:200)
Immunoprecipitation (see comments)
Immunoblotting (1:2000-1:2500; see application references)
Immunofluorescence (1:100-1:200)
Immunoprecipitation (see comments)
Avertissement
Toxicity: Highly Toxic (H)
Forme physique
Undiluted serum.
Reconstitution
Reconstitute the lyophilized antibody with 100 µl sterile distilled H₂O. Resulting reconstituted solution contains ≤0.1% sodium azide. Be careful to reconstitute the entire contents of the vial; during shipment and handling portions of the lyophilized pellet may have become dislodged and may not be in the bottom of the vial. Following reconstitution, aliquot and freeze (-20°C).
Remarque sur l'analyse
Positive Control
Rat caudate putamen or spinal cord (dorsal horn)
Rat caudate putamen or spinal cord (dorsal horn)
Autres remarques
The specificity was determined by immunolabeling of transfected cells, immunoblotting analysis, and immunoisolation studies. Antibody specificity was examined in the rat caudate putamen and dorsal horn of the spinal cord. Staining is completely eliminated by pre-treatment of antibody with immunogen peptide at a concentration of 10 µg/ml. This antibody has also been reported to work for immunopercipitation. Antibody should be titrated for optimal results in individual systems.
Zaki, P.A., et al. 1996. Annu. Rev. Pharmacol. Toxicol.36, 379.
Arvidsson, U., et al. 1995. J. Neurosci.15, 3328.
Kieffer, B.L. 1995. Cell. Mol. Neurobiol.15, 615-635.
Childers, S.R. 1991. Life Sci.48, 1991.
Arvidsson, U., et al. 1995. J. Neurosci.15, 3328.
Kieffer, B.L. 1995. Cell. Mol. Neurobiol.15, 615-635.
Childers, S.R. 1991. Life Sci.48, 1991.
Informations légales
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
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Code de la classe de stockage
10 - Combustible liquids
Classe de danger pour l'eau (WGK)
WGK 1
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Certificats d'analyse (COA)
Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".
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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.
Heng Xu et al.
The Journal of pharmacology and experimental therapeutics, 315(1), 248-255 (2005-07-01)
A growing body of literature indicates that chronic morphine exposure alters the expression and function of cytoskeletal proteins in addition to the well established interactions between mu opioid receptors and G proteins. In the present study, we hypothesized that chronic
Belén Gago et al.
Journal of neuroscience research, 91(12), 1533-1540 (2013-09-17)
The peptides dynorphin and enkephalin modulate many physiological processes, such as motor activity and the control of mood and motivation. Their expression in the caudate putamen (CPu) is regulated by dopamine and opioid receptors. The current work was designed to
Heng Xu et al.
Synapse (New York, N.Y.), 61(3), 166-175 (2006-12-08)
Previous studies established that Tyr-D-Ala-Gly-N-Me-Phe-Gly-ol (DAMGO) and (2S,4aR,6aR,7R,9S,10aS,10bR)-9-(Benzoyloxy)-2-(3-furanyl)dodecahydro-6a,10b-dimethyl-4,10-dioxo-2H-naphtho-[2,1-c]pyran-7-carboxylic acid methyl ester (herkinorin) are fully efficacious mu-agonists. Herkinorin (HERK), unlike DAMGO, does not recruit beta-arrestin and promote mu-receptor internalization, even in cells that over express beta-arrestin. We hypothesized that chronic HERK
Alicia Rivera et al.
Cells, 11(1) (2022-01-12)
Long-term exposition to morphine elicits structural and synaptic plasticity in reward-related regions of the brain, playing a critical role in addiction. However, morphine-induced neuroadaptations in the dorsal striatum have been poorly studied despite its key function in drug-related habit learning.
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