MABN2430M

Anti-Kallikrein 7 (KLK7) Antibody, clone 83-1

clone 83-1, from mouse

• Synonyme(s) : Serine protease 6, EC 3.4.21.117, hK7, Stratum corneum chymotryptic enzyme, hSCCE
• Code UNSPSC : 12352203
• eCl@ss : 32160702
• Nomenclature NACRES : NA.43

Propriétés

• Source biologique: mouse
• Niveau de qualité: 100
• Forme d'anticorps: purified immunoglobulin
• Type de produit anticorps: primary antibodies
• Clone: 83-1, monoclonal
• Espèces réactives: human
• Conditionnement: antibody small pack of 25 μg
• Technique(s): ELISA: suitable; western blot: suitable
• Isotype: IgG1κ
• Numéro d'accès NCBI: NP_005037
• Numéro d'accès UniProt: P49862
• Modification post-traductionnelle de la cible: unmodified
• Informations sur le gène: human ... KLK7(5650)

Description

Description générale

Kallikrein-7 (UniProt: P49862; also known as hK7, KLK7, Serine protease 6, Stratum corneum chymotryptic enzyme, hSCCE) is encoded by the KLK7 (also known as PRSS6, SCCE) gene (Gene ID: 5650) in human. KLK7 is a chymotrypsin-like serine protease of the member of peptidase S1 family. It is synthesized with a signal peptide of 22 amino acids (aa 1-22) and a propeptide region (aa 23-29) that are subsequently cleaved to generate the mature form. Human KLK7 displays about 40 to 60% amino acid homology with other members of the family. It cleaves proteins with aromatic side chains in the P1 position. KLK7 is abundantly expressed in the skin and is also present in the brain, mammary gland, cerebellum, spinal cord, and kidney. Lower levels of expression have been reported in in salivary glands, uterus, thymus, thyroid, placenta, trachea, and testis. Its levels are shown to be up-regulated in ovarian carcinoma, especially late-stage serous carcinoma. Less differentiated tumors of more advanced stage show higher level KLK7 expression. KLK7 activity is inhibited by zinc and copper ions.

Spécificité

Clone 83-1 detects Kallikrein -7 in human tissues.

Immunogène

Full-length human recombinant Kallikrein-7.

Application

Anti-Kallikrein 7 (KLK7), clone 83-1, Cat. No. MABN2430, is a highly specific mouse monoclonal antibody that targets Kallikrein-7 and has been tested in ELISA and Western Blotting.

ELISA Analysis: A representative lot detected Kallikrein 7 (KLK7) in ELISA applications (Shan, S.J., et. al. (2006). Clin Chem. 52(10):1879-86; Kishi, T., et. al. (2004). Clin Chem. 50(4):709-16).

Research Category
Neuroscience

Qualité

Evaluated by Western Blotting in human brain tissue lysate.

Western Blotting Analysis: 0.5 µg/mL of this antibody detected Kallikrein 7 (KLK7) in 10 µg of human brain tissue lysate.

Description de la cible

~27 kDa observed; 27.53 kDa calculated. Uncharacterized bands may be observed in some lysate(s).

Forme physique

Format: Purified

Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Sodium bicarbonate buffer, pH 8.2 with 0.02% sodium azide.

Stockage et stabilité

Stable for 1 year at 2-8°C from date of receipt.

Autres remarques

Concentration: Please refer to lot specific datasheet.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informations sur la sécurité

• Code de la classe de stockage: 12 - Non Combustible Liquids
• Classe de danger pour l'eau (WGK): nwg
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable