MABD55

Anti-TERT (human) Antibody, clone 2C4

clone 2C4, from mouse

• Synonyme(s) : Telomerase reverse transcriptase, HEST2, Telomerase catalytic subunit, Telomerase-associated protein 2, Short name=TP2
• Code UNSPSC : 12352203
• eCl@ss : 32160702
• Nomenclature NACRES : NA.41

Propriétés

• Source biologique: mouse
• Niveau de qualité: 100
• Forme d'anticorps: purified immunoglobulin
• Type de produit anticorps: primary antibodies
• Clone: 2C4, monoclonal
• Espèces réactives: human
• Technique(s): immunocytochemistry: suitable; immunoprecipitation (IP): suitable; western blot: suitable
• Isotype: IgMκ
• Numéro d'accès NCBI: NP_001180305
• Numéro d'accès UniProt: O14746
• Conditions d'expédition: wet ice
• Modification post-traductionnelle de la cible: unmodified
• Informations sur le gène: human ... TERT(7015)

Description

Description générale

Human telomerase reverse transcriptase (hTERT) is the catalytic subunit of the telomerase. It is also responsible for addition of TTAGGG repeats to the telomere ends of the chromosome, which is important in maintaining cell immortality. In most normal human cells the expression of hTERT is very low. On the other hand, greater than 90 % of human tumors of different pathology and origins have been shown to upregulate telomerase expression, making hTERT a cancer-associated target.

Immunogène

Full length recombinant protein corresponding to human TERT.

Application

Anti-TERT (human) Antibody, clone 2C4 is an antibody against TERT (human) for use in WB, IC & IP.

Immunoprecipitation Analysis: A representative lot was used by an independent laboratory to detect TERT in HeLa cells (Masutomi, K., et al. (2003). Cell, Vol. 114:241–253).

Immunocytochemistry Analysis: A representative lot was used by an independent laboratory to detect TERT in HeLa cells, BJ and WI-38 fibroblasts (Masutomi, K., et al. (2003). Cell, Vol. 114:241–253).

Qualité

Evaluated by Western Blot in human lymph node tissue lysate.

Western Blot Analysis: A 1:2,000 dilution of this antibody detected TERT in 10 µg of human lymph node tissue lysate.

Description de la cible

~90 kDa observed.
Three isoforms exist for human TERT: Isoform 1 at 127 kDa, Isoform 2 at 90 kDa, and Isoform 3 at 120 kDa

Forme physique

Format: Purified

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable