ABS456

Anti-WNT10A Antibody

from rabbit, purified by affinity chromatography

• Synonyme(s) : Protein Wnt-10a, Wingless-type MMTV integration site family 10a
• Code UNSPSC : 12352203
• eCl@ss : 32160702
• Nomenclature NACRES : NA.41

Propriétés

• Source biologique: rabbit
• Forme d'anticorps: affinity isolated antibody
• Type de produit anticorps: primary antibodies
• Clone: polyclonal
• Produit purifié par: affinity chromatography
• Espèces réactives: mouse, human
• Technique(s): immunofluorescence: suitable; immunohistochemistry: suitable (paraffin); western blot: suitable
• Numéro d'accès UniProt: Q9GZT5
• Conditions d'expédition: wet ice
• Informations sur le gène: human ... WNT10A(80326)

Description

Description générale

Wingless-type MMTV integration site family 10a (WNT10A) plays crucial role in normal development such as regulation of cell fate, patterning during embryogenesis and neoplastic transformation. Elevated levels of WNT10A have been detected in several human tumors and cancer cell lines including colorectal cancer and chronic lymphocytic leukemia. This evidence suggests that uncontrolled Wnt signaling may contribute to the abnormal apoptosis that characterizes these malignancies. Defects in WNT10A have been shown to be related and possibly are the cause of ectodermal dysplasia anhidrotic (EDA), also known ectodermal dysplasia hypohidrotic autosomal recessive (HED). Other recent evidence had suggested that mutation in WNT10A is associated with odonto-onycho-dermal dysplasia (OODD), an autosomal recessive ectodermal dysplasia and Schopf-Schulz-Passarge syndrome (SSPS).

Immunogène

KLH-conjugated linear peptide corresponding to human WNT10A.

Application

Anti-WNT10A Antibody is a highly specific rabbit polyclonal antibody, that targets Wnt & has been tested in western blotting, IHC (Paraffin) & Immunofluorescence.

Immunohistochemistry Analysis: 10 µg/mL from a representative lot detected WNT10A in human skeletal muscle tissue.

Immunofluorescence Analysis: 20 μg/mL from a representative lot detected WNT10A in human skeletal muscle cells.

Research Category
Signaling

Research Sub Category
Developmental Signaling

Qualité

Evaluated by Western Blotting in RAW264.7 cell lysate.

Western Blotting Analysis: 2 µg/mL of this antibody detected WNT10A in 15 µg of RAW264.7 cell lysate.

Description de la cible

~46 kDa observed. Uncharacterized bands may appear in some lysate(s).

Forme physique

Antigen Affinity Purified

Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.

Stockage et stabilité

Stable for 1 year at 2-8°C from date of receipt.

Remarque sur l'analyse

Control
RAW264.7 cell lysate

Autres remarques

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable