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ABE600

Sigma-Aldrich

Anti-SATB2 Antibody

from rabbit, purified by affinity chromatography

Synonyme(s) :

DNA-binding protein SATB2, Special AT-rich sequence-binding protein 2

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About This Item

Code UNSPSC :
12352203
eCl@ss :
32160702
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Niveau de qualité

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Produit purifié par

affinity chromatography

Espèces réactives

human, mouse

Technique(s)

immunofluorescence: suitable
immunohistochemistry: suitable (paraffin)
western blot: suitable

Numéro d'accès UniProt

Conditions d'expédition

wet ice

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... SATB2(23314)

Description générale

Special AT-rich sequence-binding protein 2 (SATB2) contains 2 CUT DNA-binding domains and one homeobox DNA binding domain belonging to the CUT homeobox family. SATB2 binds to DNA at the nuclear matri or scaffold-associated regions. SATB2 is highly expressed in adult brain, moderately expressed in fetal brain, and weakly expressed in adult liver, kidney, and spinal cord. Mutations in SATB2 have been associated with cleft palate.

Spécificité

This antibody recognizes the N-terminus of SATB2.

Immunogène

Epitope: N-terminus
KLH-conjugated linear peptide corresponding to the N-terminus of human SATB2.

Application

Detect Special AT-rich sequence-binding protein 2 using this rabbit polyclonal antibody, Anti-SATB2 Antibody validated for use in western blotting, IHC (Paraffin) & Immunofluorescence.
Immunohistochemistry Analysis: 5 µg/mL from a representative lot detected SATB2 in human brain tissue.

Immunofluorescence Analysis: 20 μg/mL from a representative lot detected SATB2 in human brain cells.
Research Category
Epigenetics & Nuclear Function
Research Sub Category
Transcription Factors

Qualité

Evaluated by Western Blotting in mouse brain tissue lysate.

Western Blotting Analysis: 4 µg/mL of this antibody detected SATB2 in 15 µg of mouse brain tissue lysate.

Description de la cible

~90 kDa observed

Forme physique

Antigen Affinity Purified
Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.

Stockage et stabilité

Stable for 1 year at 2-8°C from date of receipt.

Remarque sur l'analyse

Control
Mouse brain tissue lysate

Autres remarques

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

12 - Non Combustible Liquids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable


Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Lei Wang et al.
Proceedings of the National Academy of Sciences of the United States of America, 119(38), e2206147119-e2206147119 (2022-09-13)
The neocortex, the center for higher brain function, first emerged in mammals and has become massively expanded and folded in humans, constituting almost half the volume of the human brain. Primary microcephaly, a developmental disorder in which the brain is
Lei Wang et al.
Nature neuroscience, 19(7), 888-896 (2016-05-24)
The unique mental abilities of humans are rooted in the immensely expanded and folded neocortex, which reflects the expansion of neural progenitors, especially basal progenitors including basal radial glia (bRGs) and intermediate progenitor cells (IPCs). We found that constitutively active

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