625625

Trehalose, Dihydrate

Non-reducing disaccharide which yields 2 moles of D-glucose upon acid hydrolysis. Inhibits polyglutamine-mediated protein aggregation both in vivo and in vitro.

• Synonyme(s) : Trehalose, Dihydrate, 1-O-α-D-Glucopyranosyl-α-D-glucopyranoside
• Formule empirique (notation de Hill): C₁₂H₂₂O₁₁ · 2H₂O
• Numéro CAS: 6138-23-4
• Poids moléculaire : 378.33
• Numéro MDL: MFCD00071594
• Code UNSPSC : 12352201
• Nomenclature NACRES : NA.79

Propriétés

• Niveau de qualité: 100
• Pureté: ≥97.5% (by Assay)
• Forme: solid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze
• Solubilité: water: 100 mg/mL
• Traces de cations: Fe: <5 ppm; heavy metals: <10 ppm
• Conditions d'expédition: ambient
• Température de stockage: 15-25°C
• InChI: 1S/C12H22O11.2H2O/c13-1-3-5(15)7(17)9(19)11(21-3)23-12-10(20)8(18)6(16)4(2-14)22-12;;/h3-20H,1-2H2;2*1H2/t3-,4-,5-,6-,7+,8+,9-,10-,11-,12-;;/m1../s1
• Clé InChI: DPVHGFAJLZWDOC-PVXXTIHASA-N

Description

Description générale

Non-reducing disaccharide that yields 2 moles of D-glucose upon acid hydrolysis. Inhibits polyglutamine-mediated protein aggregation both in vivo and in vitro. Oral administration of trehalose has been shown to effectively extend lifespan in a murine Huntington disease model. Also known to accumulate in osmotically-stressed cultured bacterial cells and protect against the adverse effects of dehydration. Reported to prevent myoglobin collapse and preserve its internal mobility.

Non-reducing disaccharide which yields 2 moles of D-glucose upon acid hydrolysis. Inhibits polyglutamine-mediated protein aggregation both in vivo and in vitro. Oral administration of trehalose has been shown to effectively extend lifespan in a murine Huntington disease model. Also known to accumulate in osmotically-stressed cultured bacterial cells and protect against the adverse effects of dehydration.

Avertissement

Toxicity: Standard Handling (A)

Autres remarques

Sarkar, S., et al. 2007. J. Biol. Chem. In press.
Tanaka, M., et al. 2004. Nat. Med.10, 148.
Sastry, G.M. and Agmon, N. 1997. Biochemistry 36, 7097.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable