603425

Threonine Dehydrogenase Inhibitor, QC1

The Threonine Dehydrogenase Inhibitor, QC1 controls the biological activity of Threonine Dehydrogenase.

• Synonyme(s) : Threonine Dehydrogenase Inhibitor, QC1, N-Benzyl-4-oxo-2-thioxo-3-(3-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydroquinazoline-7-carboxamide
• Formule empirique (notation de Hill): C₂₃H₁₆F₃N₃O₂S
• Numéro CAS: 403718-45-6
• Poids moléculaire : 455.45
• Numéro MDL: MFCD02649259
• Code UNSPSC : 12352200

Propriétés

• Niveau de qualité: 100
• Pureté: ≥96% (HPLC)
• Forme: powder
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; protect from light
• Couleur: white
• Solubilité: DMSO: 50 mg/mL
• Conditions d'expédition: ambient
• Température de stockage: 2-8°C

Description

Description générale

A cell-permeable quinazolinecarboxamide (QC) compound that acts as a potent, reversible and mixed noncompetitive inhibitor of threonine dehydrogenase activity (IC₅₀ ~ 0.5 µM for mTDH) with excellent selectivity over hydroxysteroid, alcohol, lactate, or glucose-6-phosphate dehydrogenases (IC₅₀ >10 µM). Shown to block threonine catabolism, induce autophagy and impede the growth of highly proliferating mouse embryonic stem cells (mESCs; EC₅₀ ~3 µM) with no effect on ESCs-derived embryoid body cells, 3T3 fibroblasts or tumor cells (EC₅₀ ~1 mM).

Conditionnement

Packaged under inert gas

Avertissement

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Autres remarques

Alexander, P.B., et al. 2011. Proc. Natl. Acad. Sci. USA108, 15828.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable