444898

Mastoparan

A cell-permeable synthetic peptide with sequence identical to Vespula lewisii.

• Synonyme(s) : Mastoparan, INLKALAALAKKIL
• Formule empirique (notation de Hill): C₇₀H₁₃₁N₁₉O₁₅
• Numéro CAS: 72093-21-1
• Poids moléculaire : 1478.91
• Numéro MDL: MFCD00076865
• Code UNSPSC : 51111800
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Pureté: ≥97% (HPLC)
• Forme: solid
• Puissance: 7.5 μM IC₅₀
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze
• Couleur: white
• Solubilité: water: 5 mg/mL
• Conditions d'expédition: ambient
• Température de stockage: −20°C
• InChI: 1S/C70H131N19O15/c1-17-40(11)55(75)69(103)88-53(35-54(74)90)68(102)87-52(34-39(9)10)67(101)83-46(25-19-22-28-71)62(96)78-45(16)61(95)86-50(32-37(5)6)65(99)79-42(13)58(92)77-43(14)60(94)85-51(33-38(7)8)66(100)80-44(15)59(93)81-47(26-20-23-29-72)63(97)82-48(27-21-24-30-73)64(98)89-56(41(12)18-2)70(104)84-49(57(76)91)31-36(3)4/h36-53,55-56H,17-35,71-73,75H2,1-16H3,(H2,74,90)(H2,76,91)(H,77,92)(H,78,96)(H,79,99)(H,80,100)(H,81,93)(H,82,97)(H,83,101)(H,84,104)(H,85,94)(H,86,95)(H,87,102)(H,88,103)(H,89,98)/t40-,41?,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53-,55-,56-/m0/s1
• Clé InChI: MASXKPLGZRMBJF-HDSAQESISA-N

Description

Description générale

A cell-permeable synthetic peptide with a sequence identical to Vespula lewisii. Amphiphilic wasp venom tetradecapeptide capable of directly activating pertussis toxin-sensitive G-proteins by a mechanism analogous to that of G-protein-coupled receptors. Acts preferentially on G_i and G_o rather than G_s. Potent factor in mitochondrial permeability transition pore. Inhibits calmodulin and activates phospholipase A₂. Causes a transient Ca²⁺ release from the sarcoplasmic reticulum.

A cell-permeable synthetic peptide with sequence identical to Vespula lewisii. Amphiphilic wasp venom tetradecapeptide capable of directly activating pertussis toxin-sensitive G-proteins by a mechanism analogous to that of G-protein-coupled receptors. Acts preferentially on G_i and G_o rather than G_s. Potent facilitator of the mitochondrial permeability transition pore that is reported to induce apoptosis in cultured cerebellar granule neurons by causing a dramatic increase in intracellular Ca²⁺. Acts as a calmodulin antagonist and activates phospholipase A₂. Causes a transient Ca²⁺ release from the sarcoplasmic reticulum. Also reported to inhibit Na⁺,K⁺-ATPase activity (IC₅₀ = 7.5 µM).

Actions biochimiques/physiologiques

Cell permeable: yes

Primary Target
Na⁺,K⁺-ATPase activity

Product does not compete with ATP.

Reversible: no

Conditionnement

Yes

Avertissement

Toxicity: Standard Handling (A)

Séquence

H-Ile-Asn-Leu-Lys-Ala-Leu-Ala-Ala-Leu-Ala-Lys-Lys-Ile-Leu-NH₂

Forme physique

Supplied as a trifluoroacetate salt.

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Autres remarques

Hirata, Y., et al. 2000. Mol. Pharmacol. 57, 1235.
Liz, S.Z., et al. 1997. Brain Res.771, 184.
Klinker, J.F., et al. 1996. Biochem. Pharmacol. 51, 217.
Langel, U., et al. 1996. Regul. Peptides 62, 47.
Pfeiffer, D.R., et al. 1995. J. Biol. Chem. 270, 4923.
Igarashi, M., et al. 1993. Science259, 77.
Komatsu, M., et al. 1992. Endocrinology130, 221.
Adolfo Garcia-Sainz, J., et al. 1991. Biochem. Biophys. Res. Commun.179, 852.
Gil, J., et al. 1991. J. Cell Biol. 113, 943.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable