444285

MMP-2/MMP-9 Inhibitor V - CAS 869577-53-7 - Calbiochem

The MMP-2/MMP-9 Inhibitor V, also referenced under CAS 869577-53-7, controls the biological activity of MMP-2/MMP-9. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

• Synonyme(s) : MMP-2/MMP-9 Inhibitor V - CAS 869577-53-7 - Calbiochem, (4-(4-(Methanesulfonamido)phenoxy)phenylsulfonyl)methylthiirane, SB-3CT, pMS
• Formule empirique (notation de Hill): C₁₆H₁₇NO₅S₃
• Numéro CAS: 869577-53-7
• Poids moléculaire : 399.50
• Code UNSPSC : 12352200

Propriétés

• Niveau de qualité: 100
• Pureté: ≥85% (HPLC)
• Forme: solid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; protect from light
• Couleur: white
• Solubilité: DMSO: 200 mg/mL
• Conditions d'expédition: ambient
• Température de stockage: −20°C

Description

Description générale

A cell-permeable sulfonamido analog of SB-3CT (Cat. No. 444274) that displays enhanced aqueous solubility and improved selectivity (K_i = 16 nM, 180 nM, and 900 nM for MMP-2, MMP-9, and MMP-14, respectively). Inhibits MMP-3, MMP-7, and MMP-1 only at much higher concentrations (K_i = 3.6 µM, 295 µM, and >25 µM, respectively). Binds to the enzyme active site and acts as an irreversible inhibitor. Reported to potently suppress cell migration and invasion of HT1080 cells (80% inhibition at 2 µM and >25% inhibition at 100 nM, respectively). Unlike the general MMP inhibitor GM6001 (Cat. No. 364205), this inhibitor does not block the activation of cellular pro-MMP-2 by MT1-MMP.

Actions biochimiques/physiologiques

Cell permeable: yes

Product does not compete with ATP.

Reversible: no

Target K_i: 16 nM, 180 nM, and 900 nM for MMP-2, MMP-9, and MMP-14, respectively

Conditionnement

Packaged under inert gas

Avertissement

Toxicity: Standard Handling (A)

Autres remarques

Ikejiri, M., et al. 2005. J. Biol. Chem.280, 33992.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 10-13 - German Storage Class 10 to 13