328500

ERO1 Inhibitor I, Erodoxin

The ERO1 Inhibitor I, Erodoxin controls the biological activity of ERO1.

• Synonyme(s) : ERO1 Inhibitor I, Erodoxin, 1-Bromo-5-methoxy-2,4-dinitrobenzene, Endoplasmic Reticulum Oxidase 1 Inhibitor
• Formule empirique (notation de Hill): C₇H₅BrN₂O₅
• Numéro CAS: 181995-71-1
• Poids moléculaire : 277.03
• Numéro MDL: MFCD00624873
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.28

Propriétés

• Niveau de qualité: 100
• Pureté: ≥99% (HPLC)
• Forme: solid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; protect from light
• Couleur: yellow
• Solubilité: DMSO: 100 mg/mL (Use only fresh DMSO)
• Conditions d'expédition: wet ice
• Température de stockage: 2-8°C
• Chaîne SMILES: BrC(C=C(C([N+]([O-])=O)=C1)OC)=C1[N+]([O-])=O

Description

Description générale

A cell-permeable dinitrobromobenzene compound that acts as a selective inhibitor of yeast Endoplasmic Reticulum Oxidase 1 (ERO1), but has somewhat weaker activity against mouse ERO1α (IC₅₀ = 400 µM). Predicted to form thiol adducts and inhibits ERO1-dependent oxidation of thioredoxin-1 (Trx1) activity in vitro. Shown to cluster with genes involved in protein folding, glycosylation and cell wall biosynthesis, and delay carboxypeptidase Y (CPY) processing to the vacuolar form in wt-yeast cells.

Conditionnement

Packaged under inert gas

Avertissement

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze(-20°C). Stock solutions are stable for up to 1 month at -20°C.

Autres remarques

Costanzo, M., et al. 2010. Science327, 425.
Blais, J.D., et al. 2010. J. Biol. Chem.285, 20993.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable