14-674-M
EphB1 Protein, active, 250 µg
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About This Item
Code UNSPSC :
12352202
eCl@ss :
32160405
Nomenclature NACRES :
NA.32
Produit recombinant
expressed in baculovirus infected Sf21 cells
Niveau de qualité
Description
protein target EphB1
Produit purifié par
(Ni2+/NTA-agarose)
Technique(s)
activity assay: suitable
Numéro d'accès UniProt
Informations sur le gène
human ... EPHB1(2047)
Description générale
FUNCTION: SwissProt: P54762 # Receptor for members of the ephrin-B family. Binds to ephrin-B1, -B2 and -B3. May be involved in cell-cell interactions in the nervous system.
SIZE: 984 amino acids; 109885 Da
SUBUNIT: The ligand-activated form interacts with GRB2, GRB10 and NCK through their respective SH2 domains. The GRB10 SH2 domain binds EPHB1 through Tyr-928, while GRB2 binds residues within the catalytic domain. The NCK SH2 domain binds EPHB1 through Tyr-594. Interacts with PRKCABP (By similarity).
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
TISSUE SPECIFICITY: Preferentially expressed in brain.
SIMILARITY: SwissProt: P54762 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily. & Contains 2 fibronectin type-III domains. & Contains 1 protein kinase domain. & Contains 1 SAM (sterile alpha motif) domain.
SIZE: 984 amino acids; 109885 Da
SUBUNIT: The ligand-activated form interacts with GRB2, GRB10 and NCK through their respective SH2 domains. The GRB10 SH2 domain binds EPHB1 through Tyr-928, while GRB2 binds residues within the catalytic domain. The NCK SH2 domain binds EPHB1 through Tyr-594. Interacts with PRKCABP (By similarity).
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
TISSUE SPECIFICITY: Preferentially expressed in brain.
SIMILARITY: SwissProt: P54762 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily. & Contains 2 fibronectin type-III domains. & Contains 1 protein kinase domain. & Contains 1 SAM (sterile alpha motif) domain.
Conditionnement
Also available in 10 μg size (cat#14-674) and in bulk (cat# 14-674-K).
Qualité
routinely evaluated by phosphorylation of 250μM Src Substrate Peptide (Catalog # 12-140
Propriétés physiques
51.4kDa
Stockage et stabilité
6 months at -70°C from date of shipment
Remarque sur l'analyse
For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Clause de non-responsabilité
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Certificats d'analyse (COA)
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