14-347-M

CHK2 Protein, active, 10 µg

Active, recombinant human CHK2, residues 5-543, containing N-terminal GST & C-terminal His-6 tags, for use in Kinase Assays.

• Code UNSPSC : 12352202
• eCl@ss : 32160405
• Nomenclature NACRES : NA.32

Propriétés

• Source biologique: human
• Niveau de qualité: 100
• Produit recombinant: expressed in E. coli
• Gamme de produits: Upstate^®
• Activité spécifique: (For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.)
• Poids mol.: M_w 89.6 kDa
• Produit purifié par: (glutathione-agarose and Ni²⁺/NTA-agarose)
• Espèces réactives: human
• Fabricant/nom de marque: Upstate^®
• Technique(s): activity assay: suitable (kinase)
• Numéro d'accès: (FUNCTION: SwissProt: O96017 # Regulates cell cycle checkpoints and apoptosis in response to DNA damage, particularly to DNA double-strand breaks. Inhibits CDC25C phosphatase by phosphorylation on ′Ser-216′, preventing the entry into mitosis. May also play a role in meiosis. Regulates the TP53 tumor suppressor through phosphorylation at ′Thr-18′ and ′Ser-20′. ); NM_001005735.1
• Numéro d'accès NCBI: NM_001005735.1; NM_007194.3; NM_145862.2
• Numéro d'accès UniProt: O96017
• Informations sur le gène: human ... CHEK2(11200)

Description

Description générale

Recombinant human CHK2, residues 5-543, containing N-terminal GST and Cterminal His6 tags

Actions biochimiques/physiologiques

Protein Target: CHK2

Target Sub-Family: CAMK

Conditionnement

Also available in 10 μg size and in bulk

Also available in 250 µg size --call for pricing and availability and reference catalog number 14-347M when ordering the 250 µg size.

Qualité

routinely evaluated by phosphorylation of the CHKtide substrate peptide

Description de la cible

CHK2

Forme physique

glutathione-agarose and Ni²⁺/NTA-agarose

Stockage et stabilité

1 year at -70°C

Autres remarques

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

Informations légales

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H317
• Conseils de prudence: P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364
• Classification des risques: Skin Sens. 1
• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°C): Not applicable