07-724
Anti-α-Insulin Receptor Antibody, β subunit
Upstate®, from rabbit
Synonyme(s) :
CD220 antigen, insulin receptor
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About This Item
Code UNSPSC :
12352203
eCl@ss :
32160702
Nomenclature NACRES :
NA.41
Produits recommandés
Source biologique
rabbit
Niveau de qualité
Forme d'anticorps
affinity isolated antibody
Type de produit anticorps
primary antibodies
Clone
polyclonal
Produit purifié par
affinity chromatography
Espèces réactives
mouse, human, rat
Réactivité de l'espèce (prédite par homologie)
chimpanzee
Fabricant/nom de marque
Upstate®
Technique(s)
immunoprecipitation (IP): suitable
western blot: suitable
Numéro d'accès NCBI
Numéro d'accès UniProt
Conditions d'expédition
wet ice
Modification post-traductionnelle de la cible
unmodified
Informations sur le gène
human ... INSR(3643)
Description générale
The insulin receptor is a tyrosine kinase receptor that when bound to insulin, initiates multiple signal transduction pathways, including JNK, PI 3-kinase, Akt and PKC. Pharmacological intervention of these Insulin R-dependent pathways is of great interest for the treatment of insulin resistance, obesity and diabetes. The Insulin Receptor (IR) is synthesized as a single polypeptide, which is subsequently cleaved to generate an extracellular α-chain and a transmembrane and intracellular β-chain, tethered together by disulfide bonds. The β-chain has multiple tyrosine phosphorylation sites, including three autophosphorylation sites at its activation loop. The overall structure of the IR is highly homologous to the IGF-I Receptor, except in their c-termini, where the two proteins diverge somewhat. The IR signals primarily by phosphorylating the Insulin Receptor Substrate (IRS) family of proteins, which creates docking sites for SH2-domain containing proteins. Insulin signaling is highly dependent on the PI3 Kinase pathway and Akt, which appear to mediate the functions of insulin.
Spécificité
This antibody recognizes α-Insulin Receptor, β subunit.
Immunogène
Epitope: C-terminus
GST-fusion protein corresponding to the last 100 C-terminal amino acid residues of the human insulin receptor β chain
Application
Anti-α-Insulin Receptor Antibody, β subunit is an antibody against a-Insulin Receptor for use in IP & WB.
Immunoprecipitation Analysis:
Research Category
Signaling
Metabolism
Signaling
Metabolism
Research Sub Category
Insulin/Energy Signaling
Insulin/Energy Signaling
Qualité
Evaluated by Western Blot in Human brain tissue lysate.
Western Blot Analysis: : 1:1,000 dilution of this antibody detected α-Insulin Receptor, β subunit in human brain tissue lysate.
Western Blot Analysis: : 1:1,000 dilution of this antibody detected α-Insulin Receptor, β subunit in human brain tissue lysate.
Description de la cible
97 kDa
Forme physique
Affinity purified
Purified rabbit polyclonal serum in buffer containing 0.1 M Tris-glycine, pH 7.4, 150 mM NaCl and 0.05% sodium azide.
Stockage et stabilité
Maintain refrigerated at 2-8°C for for 1 year from date of receipt.
Remarque sur l'analyse
Control
Human brain tissue lysate
Human brain tissue lysate
Autres remarques
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Informations légales
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Clause de non-responsabilité
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Réf. du produit
Description
Tarif
Code de la classe de stockage
10 - Combustible liquids
Classe de danger pour l'eau (WGK)
WGK 1
Certificats d'analyse (COA)
Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".
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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.
Makoto Takahashi et al.
Oncology reports, 37(5), 2929-2941 (2017-04-11)
We investigated the relationship among serum insulin level, insulin receptor (IR) expression in renal cell carcinoma (RCC), and outcomes in patients with RCC who underwent nephrectomy. We also explored the role of insulin signaling in RCC progression in a murine RCC
Insulin receptor and IRS-1 co-immunoprecipitation with SOCS-3, and IKK?/? phosphorylation are increased in obese Zucker rat skeletal muscle.
Zolotnik, IA; Figueroa, TY; Yaspelkis, BB
Life Sciences null
Michael E Cox et al.
The Prostate, 69(1), 33-40 (2008-09-12)
Although recent laboratory and population studies suggest that prostate cancer may be responsive to insulin, there is a gap in knowledge concerning the expression of insulin receptors on benign or malignant prostate tissue. We immunostained 644 cores on tissue microarrays
Redistribution of glycolipid raft domain components induces insulin-mimetic signaling in rat adipocytes.
Muller, G, et al.
Molecular and cellular biology, 21, 4553-4567 (2001)
Thomas U Ahearn et al.
Carcinogenesis, 39(12), 1431-1437 (2018-08-31)
Circulating insulin-like growth factor-1 (IGF-1) is consistently associated with prostate cancer risk. IGF-1 binds to IGF-1 receptor (IGF1R) and insulin receptor (IR), activating cancer hallmark pathways. Experimental evidence suggests that TMPRSS2:ERG may interact with IGF/insulin signaling to influence progression. We
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