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07-337

Sigma-Aldrich

Anti-SOS1 Antibody, CT

Upstate®, from rabbit

Synonyme(s) :

Anti-Anti-GF1, Anti-Anti-GGF1, Anti-Anti-GINGF, Anti-Anti-HGF, Anti-Anti-NS4, Anti-Anti-SOS-1

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About This Item

Code UNSPSC :
12352203
eCl@ss :
32160702
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Niveau de qualité

100

Forme d'anticorps

purified immunoglobulin

Type de produit anticorps

primary antibodies

Clone

polyclonal

Espèces réactives

mouse, human

Fabricant/nom de marque

Upstate®

Technique(s)

immunoprecipitation (IP): suitable
western blot: suitable

Isotype

IgG

Numéro d'accès NCBI

NM_005633

Numéro d'accès UniProt

Q07889

Conditions d'expédition

wet ice

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... SOS1(6654)

Spécificité

SOS1

Immunogène

peptide corresponding to amino acids 1243-1258 (KKSDHGNAFFPNSPSP) of murine Son of Sevenless Homolog 1 Protein (SOS 1)

Application

Anti-SOS1 Antibody, CT is an antibody against SOS1 for use in IP & WB.
Research Category
Signaling
Research Sub Category
MAP Kinases

Qualité

routinely evaluated by immunoblot on 3T3/A31, A431 cell lysates, or HeLa nuclear extracts

Description de la cible

175 kDa

Forme physique

Format: Purified
Protein A chromatography
Protein A purified Rabbit Ig in 0.1M Tris-Glycine, 0.15M NaCl, 0.05% Sodium Azide, pH 7.4.

Stockage et stabilité

Stable for 1 year at 2-8°C from date of receipt.

Remarque sur l'analyse

Control
Positive Antigen Control: Catalog #12-305, 3T3/A31 lysate. Add 2.5 μL of 2-mercapto-ethanol/100 μL of lysate and boil for 5 minutes to reduce the preparation. Load 20 μg of reduced lysate per lane for minigels.

Informations légales

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

12 - Non Combustible Liquids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

T cell receptor-induced phosphorylation of Sos requires activity of CD45, Lck, and protein kinase C, but not ERK.
Zhao, H, et al.
The Journal of Biological Chemistry, 272, 21625-21634 (1997)
J Ng et al.
The Journal of biological chemistry, 272(39), 24542-24549 (1997-09-26)
Interleukin 2 (IL-2) induces tyrosine phosphorylation of STATs 3 and 5 (signal transducer and activator of transcription). We now show that IL-2 regulation of STAT3 proteins in T cells is a complex response involving activation of two forms of STAT3:
Somatostatin receptors 1 and 5 heterodimerize with epidermal growth factor receptor: agonist-dependent modulation of the downstream MAPK signalling pathway in breast cancer cells.
Heather L Watt,Geetanjali D Kharmate,Ujendra Kumar
Cellular Signalling null
Michael Bordonaro et al.
Cancers, 8(5) (2016-05-18)
Although neoplastic cells exhibit relatively higher sensitivity to hyperthermia than normal cells, hyperthermia has had variable success as an anti-cancer therapy. This variable outcome might be due to the fact that cancer cells themselves have differential degrees of sensitivity to
Stéphane Pierre et al.
Biochemical pharmacology, 81(2), 304-313 (2010-10-19)
TCDD (2,3,7,8-tetrachlorodibenzodioxin), a highly persistent environmental pollutant and a human carcinogen, is the ligand with the highest affinity for the Aryl Hydrocarbon Receptor (AhR) that induces via the AhR, xenobiotic metabolizing enzyme genes as well as several other genes. This

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