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F-052

Supelco

Furosemide Impurity Mixture solution

5 μg/mL (50:50 Acetonitrile:Water, each analyte), certified reference material, ampule of 1 mL, Cerilliant®

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About This Item

Formule empirique (notation de Hill) :
C12H11ClN2O5S
Poids moléculaire :
330.74
Code UNSPSC :
12352200
Nomenclature NACRES :
NA.24

Qualité

certified reference material

Forme

liquid

Caractéristiques

Snap-N-Spike®/Snap-N-Shoot®

Composition

2-Chloro-4-furfurylamino-5-sulfamoylbenzoic acid, 5 μg/mL
4-Chloro-5-sulfamoylanthranilic acid (Furosemide RCB), 5 μg/mL
Furosemide, 5 μg/mL

Conditionnement

ampule of 1 mL

Fabricant/nom de marque

Cerilliant®

Concentration

5 μg/mL (50:50 Acetonitrile:Water, each analyte)

Technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

Application(s)

pharmaceutical (small molecule)

Format

multi-component solution

Température de stockage

−20°C

Description générale

Furosemide is a powerful diuretic agent with the ascending limb of Henle′s loop of nephron as its primary site of action. It works by preventing the reabsorption of sodium and increasing the secretion of renal vasodilatory prostaglandin E. In combination with nitrates, it is used as the standard treatment for pulmonary edema caused by acute heart failure.

Application

Furosemide Impurity Mixture solution may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by chromatography techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Informations légales

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Analyte

Description

    Furosemide, Pharmaceutical Secondary Standard; Certified Reference Material
    Furosemide Related Compound B, Pharmaceutical Secondary Standard; Certified Reference Material
    Furosemide Related Compound A, Pharmaceutical Secondary Standard; Certified Reference Material

Pictogrammes

FlameExclamation mark

Mention d'avertissement

Danger

Mentions de danger

Classification des risques

Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2

Code de la classe de stockage

3 - Flammable liquids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

50.0 °F

Point d'éclair (°C)

10 °C


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Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

Lack of renoprotective effects of dopamine and furosemide during cardiac surgery
Lassnigg A, et al.
Journal of the American Society of Nephrology, 11(1), 97-104 (2000)
Furosemide effect on isolated perfused tubules
Burg M, et al.
The American Journal of Physiology, 225(1), 119-124 (1973)
Furosemide
USP42/NF37: United States Pharmacopeia and National Formulary
United States Pharmacopeia/National Formulary, 41(3), 2006-2006 (2018)
Randomised trial of high-dose isosorbide dinitrate plus low-dose furosemide versus high-dose furosemide plus low-dose isosorbide dinitrate in severe pulmonary oedema
Cotter G, et al.
Lancet, 351(9100), 389-393 (1998)

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