Accéder au contenu
Merck
Toutes les photos(1)

Documents

880346P

Avanti

DChemsPC

Avanti Research™ - A Croda Brand 880346P, powder

Synonyme(s) :

1,2-dicholesterylhemisuccinoyl-sn-glycero-3-phosphocholine

Se connecterpour consulter vos tarifs contractuels et ceux de votre entreprise/organisme
Toutes les photos(1)

About This Item

Formule empirique (notation de Hill):
C70H116NO12P
Numéro CAS:
1155878-69-5
Poids moléculaire :
1194.64
Code UNSPSC :
51191904
Nomenclature NACRES :
NA.25

Forme

powder

Conditionnement

pkg of 1 × 25 mg (880346P-25mg)

Fabricant/nom de marque

Avanti Research™ - A Croda Brand 880346P

Type de lipide

cardiolipins
phospholipids

Conditions d'expédition

dry ice

Température de stockage

−20°C

Chaîne SMILES 

O=P([O-])(OCC[N+](C)(C)C)OC[C@H](OC(CCC(OC1CC[C@]2(C)C(C1)=CCC3C2CC[C@]4(C)C3CC[C@H]4[C@@H](C)CCCC(C)C)=O)=O)COC(CCC(OC5CC[C@]6(C)C(C5)=CCC7C6CC[C@]8(C)C7CC[C@H]8[C@@H](C)CCCC(C)C)=O)=O

Application

DChemsPC might be used:
  • as a substitute for cholesterol in liposome formulation to study its effect on membrane stability
  • in the preparation of pH-gradient liposomes
  • to form sterol-phospholipid hybrid with palmitoyl-2-cholesterylhemisuccinoyl-sn-glycero-3-phosphocholine (PCholPC) and to study its properties and interactions

Actions biochimiques/physiologiques

Liposome instability in blood is caused mainly due to cholesterol exchange. Sterol modified phospholipid retains the bilayer-stabilizing effect of free cholesterol, inhibiting its transfer from the bilayer. Therefore, disterolphospholipids are ideal for liposome preparation. The use of DChemsPC in liposomes prevents content leaking into the serum.

Conditionnement

5 mL Amber Glass Screw Cap Vial (880346P-25mg)

Informations légales

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

Déjà en possession de ce produit ?

Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Vincent Forster et al.
Biomaterials, 33(13), 3578-3585 (2012-02-15)
Calcium channel blocker (CCB) overdose is potentially lethal. Verapamil and diltiazem are particularly prone to acute toxicity due to their dual effect on cardiac and vascular tissues. Unfortunately, conventional decontamination measures are ineffective in accelerating blood clearance and, to date
Michał Flasiński et al.
Langmuir : the ACS journal of surfaces and colloids, 32(16), 4095-4102 (2016-04-06)
The two synthetic sterol-phospholipid hybrids DCholPC and PCholPC were investigated in monolayers at the air/water interface. Study was based on π-A isotherm analysis complemented with application of grazing incidence X-ray diffraction. It was found that both compounds are capable of
Aditya G Kohli et al.
Journal of controlled release : official journal of the Controlled Release Society, 176, 86-93 (2013-12-26)
We introduce a method for tracking the rate and extent of delivery of liposome contents in vivo based on encapsulation of 4-methylumbelliferyl phosphate (MU-P), a profluorophore of 4-methylumbelliferone (MU). MU-P is rapidly dephosphorylated by endogenous phosphatases in vivo to form
Maryam Iman et al.
International journal of pharmaceutics, 408(1-2), 163-172 (2011-02-01)
1,2-Di-stigma-steryl-hemi-succinoyl-sn-glycero-3-phosphocholine (DSHemsPC) is a new lipid in which two molecules of stigmasterol (an inexpensive plant sterol) are covalently linked via a succinic acid to glycerophosphocholine. Since amphotericin B (AmB) interacts with sterols, we postulated that DSHemsPC could be used in
F Foglia et al.
Langmuir : the ACS journal of surfaces and colloids, 27(13), 8275-8281 (2011-06-04)
Langmuir isotherm, neutron reflectivity, and small angle neutron scattering studies have been conducted to characterize the monolayers and vesicular bilayers formed by a novel chimeric phospholipid, ChemPPC, that incorporates a cholesteryl moeity and a C-16 aliphatic chain, each covalently linked
Afficher tous les articles scientifiques apparentés

Notre équipe de scientifiques dispose d'une expérience dans tous les secteurs de la recherche, notamment en sciences de la vie, science des matériaux, synthèse chimique, chromatographie, analyse et dans de nombreux autres domaines..

Contacter notre Service technique