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860626P

Avanti

C8 Dihydroceramide (d18:0/8:0)

Avanti Research™ - A Croda Brand 860626P, powder

Synonyme(s) :

N-octanoyl-D-erythro-sphinganine

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About This Item

Formule empirique (notation de Hill):
C26H53NO3
Numéro CAS:
145774-33-0
Poids moléculaire :
427.70
Code UNSPSC :
12352211
Nomenclature NACRES :
NA.25

Forme

powder

Conditionnement

pkg of 1 × 5 mg (860626P-5mg)

Fabricant/nom de marque

Avanti Research™ - A Croda Brand 860626P

Type de lipide

sphingolipids

Conditions d'expédition

dry ice

Température de stockage

−20°C

Chaîne SMILES 

OC[C@]([H])(NC(CCCCCCC)=O)[C@]([H])(O)CCCCCCCCCCCCCCC

InChI

1S/C26H53NO3/c1-3-5-7-9-10-11-12-13-14-15-16-18-19-21-25(29)24(23-28)27-26(30)22-20-17-8-6-4-2/h24-25,28-29H,3-23H2,1-2H3,(H,27,30)/t24-,25+/m0/s1

Clé InChI

LGOFBZUQIUVJFS-LOSJGSFVSA-N

Catégories apparentées

Application

C8 Dihydroceramide (d18:0/8:0) has been used as an internal standard to quantify the lipid extracted from human plasma by liquid chromatography mass spectrometry during high-throughput plasma lipidomics.

Actions biochimiques/physiologiques

C8 Dihydroceramide (d18:0/8:0) or N-octanoyl-D-erythro-sphinganine, is a synthetic dihydroceramide. Dihydroceramide acts as a precursor for de-novo ceramide synthesis. C8 Dihydroceramide mimics γ-tocotrienol (γTE) in stimulating NF-κB-target protein A20 expression, increasing endoplasmic reticulum (ER) stress and reducing tumor necrosis factor (TNF)-triggered nuclear factor kappa B (NF-κB) activation.

Conditionnement

5 mL Amber Glass Screw Cap Vial (860626P-5mg)

Informations légales

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Certificats d'analyse (COA)

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Vitamin E gamma-tocotrienol inhibits cytokine-stimulated NF-kappaB activation by induction of anti-inflammatory A20 via stress adaptive response due to modulation of sphingolipids
Wang Y, et al.
Journal of Immunology, 195(1), 126-133 (2015)
Jennifer T Saville et al.
Journal of inherited metabolic disease, 43(3), 558-563 (2019-11-11)
Gaucher disease (GD) is an inherited metabolic disorder characterised by impaired catabolism of the glycosphingolipid, glucosylceramide. The deacetylated derivative, glucosylsphingosine (GluSph, lyso-Gb1) has materialised as a biomarker for GD. Further appraisal of the clinical utility of GluSph is required in
Yun Wang et al.
Journal of immunology (Baltimore, Md. : 1950), 195(1), 126-133 (2015-05-24)
NF-κB plays a central role in pathogenesis of inflammation and cancer. Many phytochemicals, including γ-tocotrienol (γTE), a natural form of vitamin E, have been shown to inhibit NF-κB activation, but the underlying mechanism has not been identified. In this study
Low serum levels of (dihydro-) ceramides reflect liver graft dysfunction in a real-world cohort of patients post liver transplantation
Mucke V, et al.
International Journal of Molecular Sciences, 19(4), 991-991 (2018)
Victoria Therese Mücke et al.
International journal of molecular sciences, 19(4) (2018-03-29)
Patients after orthopic liver transplantation (OLT) are at risk of developing graft dysfunction. Sphingolipids (SL's) have been identified to play a pivotal role in the regulation of hepatocellular apoptosis, inflammation and immunity. We aimed to investigate the serum SL profile
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