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810219P

Avanti

C12-NBD Sphingomyelin

Avanti Research™ - A Croda Brand 810219P, powder

Synonyme(s) :

N-[12-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]dodecanoyl]-sphingosine-1-phosphocholine

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About This Item

Formule empirique (notation de Hill):
C41H73N6O9P
Numéro CAS:
254117-01-6
Poids moléculaire :
825.03
Code UNSPSC :
12352211
Nomenclature NACRES :
NA.25

Pureté

>99% (TLC)

Forme

powder

Conditionnement

pkg of 1 × 1 mg (810219P-1mg)

Fabricant/nom de marque

Avanti Research™ - A Croda Brand 810219P

Conditions d'expédition

dry ice

Température de stockage

−20°C

Catégories apparentées

Description générale

C12-NBD Sphingomyelin is a fluorescent analog of biologically active molecule, sphingomyelin. Sphingomyelin is predominantly found in the animal plasma membrane. It is abundantly present as component of cell membranes in mammals, nematodes, protozoa.

Application

C12-NBD-sphingomyelin has been used as a substrate to test substrate specificity of neutral ceramidase orthologue encoded by AsahA gene.

Actions biochimiques/physiologiques

Sphingomyelin (SM) is produced from phosphatidylcholine and ceramide on the cell surface and in lumen of the Golgi. SM′s high packing density and affinity to sterols form a rigid barrier to the extracellular environment. SM is also involved in the formation of lipid rafts in cell membranes, which perform important functions in signal transduction and membrane trafficking.

Conditionnement

5 mL Amber Glass Screw Cap Vial (810219P-1mg)

Informations légales

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Code de la classe de stockage

11 - Combustible Solids

Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

Sawaki Tada et al.
FEMS microbiology letters, 298(2), 157-165 (2009-08-05)
Ceramide is an important molecule not only structurally but also regulationally as a modulator of various cellular events. Ceramidase (CDase) are classified into three different types (acid, alkaline, and neutral CDases). Neutral CDase could play an important role in the
Fluorescent and Luminescent Probes for Biological Activity (1999)
Characterization of a neutral ceramidase orthologue from Aspergillus oryzae
Tada S, et al.
FEMS Microbiology Letters, 298(2), 157-165 (2009)
Hyun-Seok Lee et al.
International journal of molecular sciences, 21(3) (2020-02-08)
Human epidermis is positioned at the interface with the external environment, protecting our bodies against external challenges, including air pollutants. Emerging evidence suggests that diesel particulate extract (DPE), a major component of air pollution, leads to impairment of diverse cellular
Klazien Huitema et al.
The EMBO journal, 23(1), 33-44 (2003-12-20)
Sphingomyelin (SM) is a major component of animal plasma membranes. Its production involves the transfer of phosphocholine from phosphatidylcholine onto ceramide, yielding diacylglycerol as a side product. This reaction is catalysed by SM synthase, an enzyme whose biological potential can

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