791275P
Avanti
18:0 PE-DTPA (Gd)
1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-diethylenetriaminepentaacetic acid (gadolinium salt), powder
Synonyme(s) :
1,2-dioctadecanoyl-sn-glycero-3-phosphoethanolamine-N-diethylenetriaminepentaacetic acid (gadolinium salt); DSPE-DTPA (Gd)
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About This Item
Formule empirique (notation de Hill):
C55H106GdN6O17P
Numéro CAS:
Poids moléculaire :
1311.68
Code UNSPSC :
12352211
Nomenclature NACRES :
NA.25
Produits recommandés
Pureté
>99% (TLC)
Forme
powder
Conditionnement
pkg of 1 × 5 mg (791275P-5mg)
Fabricant/nom de marque
Avanti Research™ - A Croda Brand 791275P
Conditions d'expédition
dry ice
Température de stockage
−20°C
Catégories apparentées
Description générale
1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-diethylenetriaminepentaacetic acid (gadolinium salt) (18:0 PE-DTPA (Gd)) are sparing soluble in alcohol and well soluble in a solvent mixture consisting of chloroform and methanol in the ratio of 4:1, v/v. 18:0 PE-DTPA (Gd) is a synthetic phospholipid derivative ethanolamine. The DTPA is attached to gadolinium ion.
Application
18:0 PE-DTPA (Gd) has been used:
- as a component of Gadolinium-liposome preparation
- in the nanodics preparation for nuclear magnetic resonance (NMR) studies
- in construction of cysteine-arginine-glutamic acid-lysine alanine (CREKA) based peptide amphiphile micelles (PAMs) for the magnetic resonance imaging (MRI) studies
- as a spin-labeled lipid for supported lipid bilayer incorporation for cryo transmission electron microscopy studies
Actions biochimiques/physiologiques
1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-diethylenetriaminepentaacetic acid (gadolinium salt) (18:0 PE-DTPA (Gd)) phospholipid based liposomes are useful in magnetic resonance imaging (MRI) and multimodal imaging. Apart from being a MRI contrast agent, PE-DTPA (Gd) liposome is also flexible for modification for binding different targets using copper–free click–chemistry methodology.
Conditionnement
5 mL Amber Glass Screw Cap Vial (791275P-5mg)
Informations légales
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Code de la classe de stockage
11 - Combustible Solids
Classe de danger pour l'eau (WGK)
WGK 3
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Fibrin-targeting, peptide amphiphile micelles as contrast agents for molecular MRI
Chung EJ, et al.
journal of Cell Science & Therapy, 5(5), 1-1 (2014)
Supported Lipid Bilayers on Fluorescent Nanodiamonds: A Structurally Defined and Versatile Coating for Bioapplications
Vavra J, et al.
Advances in Functional Materials, 28(45), 1803406-1803406 (2018)
Zhenhao Fang et al.
Cell chemical biology, 25(11), 1327-1336 (2018-08-21)
KRAS is frequently mutated in several of the most lethal types of cancer; however, the KRAS protein has proven a challenging drug target. K-RAS4B must be localized to the plasma membrane by prenylation to activate oncogenic signaling, thus we endeavored
Jin Young Kang et al.
Immunity, 31(6), 873-884 (2009-11-26)
Toll-like receptor 2 (TLR2) initiates potent immune responses by recognizing diacylated and triacylated lipopeptides. Its ligand specificity is controlled by whether it heterodimerizes with TLR1 or TLR6. We have determined the crystal structures of TLR2-TLR6-diacylated lipopeptide, TLR2-lipoteichoic acid, and TLR2-PE-DTPA
Pavlína Šimečková et al.
Scientific reports, 10(1), 4780-4780 (2020-03-18)
Gadolinium (Gd)-based contrast agents are extensively used for magnetic resonance imaging (MRI). Liposomes are potential nanocarrier-based biocompatible platforms for development of new generations of MRI diagnostics. Liposomes with Gd-complexes (Gd-lip) co-encapsulated with thrombolytic agents can serve both for imaging and
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