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710341C

Avanti

16:0-18:1 Cardiolipin

Avanti Research™ - A Croda Brand

Synonyme(s) :

1′,3′-bis[1-Palmitoyl-2-oleoyl-sn-glycero-3-phospho]-glycerol, sodium salt

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About This Item

Formule empirique (notation de Hill):
C77H144Na2O17P2
Numéro CAS:
2260669-35-8
Poids moléculaire :
1449.88
Code UNSPSC :
51191904
Nomenclature NACRES :
NA.25

Pureté

>99% (TLC)

Forme

chloroform solution

Conditionnement

pkg of 1 × 2.5 mL (710341C-25MG)

Fabricant/nom de marque

Avanti Research™ - A Croda Brand

Concentration

10 mg/mL in chloroform (710341C-25MG)

Type de lipide

cardiolipins
phospholipids

Conditions d'expédition

dry ice

Température de stockage

−20°C

Chaîne SMILES 

O=P([O-])(OC[C@]([H])(OC(CCCCCCC/C=C\CCCCCCCC)=O)COC(CCCCCCCCCCCCCCC)=O)OCC([H])(O)COP([O-])(OC[C@]([H])(OC(CCCCCCC/C=C\CCCCCCCC)=O)COC(CCCCCCCCCCCCCCC)=O)=O.[Na+].[Na+]

Description générale

Cardiolipin is a 1,3-diphosphatidyl-sn-glycerol, a homodimeric phospholipid with four fatty acids. Cardiolipin is unique because of its atypical fatty acid composition. It is present in the mitochondrial membrane. CL species are complex in structure and several permutations exists due to variations in the chain length, degree of unsaturation, as well as combinations of four fatty acid substituents.

Actions biochimiques/physiologiques

Cardiolipin is a specific marker of mitochondria and is essential for multiple roles like energy transformation, apoptosis, and membrane integrity. 16:0-18:1 is a nascent cardiolipin acts as a precursor for the synthesis of tetralinoleoyl cardiolipin (TLCL).

Conditionnement

5 mL Amber Glass Screw Cap Vial (710341C-25MG)

Informations légales

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Souvent commandé avec ce produit

Réf. du produit
Description
Tarif

Pictogrammes

Skull and crossbonesHealth hazard
GHS06,GHS08

Mention d'avertissement

Danger

Classification des risques

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 Oral - STOT SE 3

Organes cibles

Central nervous system, Liver,Kidney

Code de la classe de stockage

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de danger pour l'eau (WGK)

WGK 3

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Molecular symmetry in mitochondrial cardiolipins
Schlame M, et al.
Chemistry and Physics of Lipids, 138(1-2), 38-49 (2005)
Characterization of cardiolipin as the sodiated ions by positive-ion electrospray ionization with multiple stage quadrupole ion-trap mass spectrometry
Hsu FF and Turk J
Journal of the American Society For Mass Spectrometry, 17(8), 1146-1157 (2006)
The phospholipase iPLA2gamma is a major mediator releasing oxidized aliphatic chains from cardiolipin, integrating mitochondrial bioenergetics and signaling
Liu GY, et al.
The Journal of Biological Chemistry, 292(25), 10672-10684 (2017)
Clare L Laut et al.
mBio, 11(2) (2020-04-03)
Bacillus anthracis is a spore-forming bacterium that causes devastating infections and has been used as a bioterror agent. This pathogen can survive hostile environments through the signaling activity of two-component systems, which couple environmental sensing with transcriptional activation to initiate
Lavanya Visvabharathy et al.
PLoS pathogens, 16(4), e1008443-e1008443 (2020-04-29)
Staphylococcus aureus (SA) is the causative agent of both skin/soft tissue infections as well as invasive bloodstream infections. Though vaccines have been developed to target both humoral and T cell-mediated immune responses against SA, they have largely failed due to
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