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ALD00528

Sigma-Aldrich

Serine Hydrolase Inhibitor-1

Synonyme(s) :

tert-Butyl 4-(pyridin-2-ylcarbamoyl)piperazine-1-carboxylate, SHI-1

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About This Item

Formule empirique (notation de Hill):
C15H22N4O3
Numéro CAS:
295341-43-4
Poids moléculaire :
306.36
Code UNSPSC :
12352200
ID de substance PubChem :
329772707
Nomenclature NACRES :
NA.22

Forme

powder

Niveau de qualité

100

Chaîne SMILES 

O=C(N1CCN(C(OC(C)(C)C)=O)CC1)NC2=NC=CC=C2

InChI

1S/C15H22N4O3/c1-15(2,3)22-14(21)19-10-8-18(9-11-19)13(20)17-12-6-4-5-7-16-12/h4-7H,8-11H2,1-3H3,(H,16,17,20)

Clé InChI

AZTUPJARVMQULZ-UHFFFAOYSA-N

Application

Serine hydrolase inhibitors are small molecule fragments that react in vitro with the serine hydrolase class of proteins. They are amenable to further modification to create novel inhibitors of this class of protein.

Pictogrammes

Skull and crossbones
GHS06

Mention d'avertissement

Danger

Mentions de danger

H301

Conseils de prudence

P301 + P330 + P331 + P310

Classification des risques

Acute Tox. 3 Oral

Code de la classe de stockage

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Katerina Otrubova et al.
Bioorganic & medicinal chemistry letters, 24(16), 3807-3813 (2014-07-20)
Two libraries of modestly reactive ureas containing either electron-deficient acyl anilines or acyl pyrazoles were prepared and are reported as screening libraries for candidate serine hydrolase inhibitors. Within each library is a small but powerful subset of compounds that serve

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