924512
NanoFabTX™- NH2 Lipid Mix
for synthesis of amine functionalized liposomes
Synonyme(s) :
Liposome, Liposome synthesis kit, Microfluidics, NanoFabTx™ liposome reagent kit, Small molecule drug formulation kit, for small molecule drug delivery
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About This Item
Code UNSPSC :
12161503
Nomenclature NACRES :
NA.23
Produits recommandés
Description
NanoFabTx™ Amine-functionalized liposome kit for small molecule encapsulation
Niveau de qualité
Application(s)
advanced drug delivery
Température de stockage
−20°C
Catégories apparentées
Description générale
NanoFabTX™- NH2 Lipid Mix; for synthesis of amine functionalized liposomes is a ready-to-use nanoformulation lipid blend that includes lyophilized lipids and step-by-step instructions for synthesizing amine functionalized liposomes for small molecule drug delivery applications. Lipid-based formulations are widely used for drug delivery and enable improved therapeutic efficacy of a range of drug types including small molecules, nucleic acids, proteins and peptides. The amine functionalized surface group allows for facile conjugation of targeting groups onto the liposome surface for targeted drug delivery.
Application
About NanoFabTx™
NanoFabTx™ is a collection of ready-to-use drug formulation kits, lipid mixes, and microfluidic device kits for the synthesis of nanocarriers and microcarriers for drug delivery. The kits enable users to encapsulate a wide variety of therapeutic drug molecules for targeted or extended drug delivery without the need for lenghty trial-and-error optimization. NanoFabTx™ provide an easy to use toolkit for encapsulating a variety of therapeutics in nanoparticles, microparticles, or liposomes. Drug encapsulated particles synthesized with the NanoFabTx™ kits are suitable for biomedical research applications such as oncology, immuno-oncology, gene delivery, and vaccine delive
NanoFabTx™ is a collection of ready-to-use drug formulation kits, lipid mixes, and microfluidic device kits for the synthesis of nanocarriers and microcarriers for drug delivery. The kits enable users to encapsulate a wide variety of therapeutic drug molecules for targeted or extended drug delivery without the need for lenghty trial-and-error optimization. NanoFabTx™ provide an easy to use toolkit for encapsulating a variety of therapeutics in nanoparticles, microparticles, or liposomes. Drug encapsulated particles synthesized with the NanoFabTx™ kits are suitable for biomedical research applications such as oncology, immuno-oncology, gene delivery, and vaccine delive
Caractéristiques et avantages
- A ready-to-use nanoformulation lipid blend for the synthesis of amine functionalized liposomes
- Step-by-step protocols (extrusion and microfluidics) developed and tested by our formulation scientists
- Flexible synthesis tool to create uniform and reproducible liposomes
- Optimized to make liposomes around 100 nm with low polydispersity
- Amine surface functionalization allows for targeting ligand conjugation to enable targeted drug delivery
- A lipid film hydration and extrusion protocol
- A microfluidics protocol using commercial platforms or syringe pumps
Informations légales
NANOFABTX is a trademark of Sigma-Aldrich Co. LLC
Produit(s) apparenté(s)
Réf. du produit
Description
Tarif
Code de la classe de stockage
11 - Combustible Solids
Classe de danger pour l'eau (WGK)
WGK 3
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Which polymers can make nanoparticulate drug carriers long-circulating?
Torchilin V P, et al.
Advanced Drug Delivery Reviews, 16, 141-155 (1995)
D Papahadjopoulos et al.
Proceedings of the National Academy of Sciences of the United States of America, 88(24), 11460-11464 (1991-12-15)
The results obtained in this study establish that liposome formulations incorporating a synthetic polyethylene glycol-derivatized phospholipid have a pronounced effect on liposome tissue distribution and can produce a large increase in the pharmacological efficacy of encapsulated antitumor drugs. This effect
Recent advances on liposomal nanoparticles: synthesis, characterization and biomedical applications.
Yunes Panahi et al.
Artificial cells, nanomedicine, and biotechnology, 45(4), 788-799 (2017-03-11)
Liposome is a new nanostructure for the encapsulation and delivery of bioactive agents. There are a lot of bioactive materials that could be incorporated into liposomes including cosmetics, food ingredients, and pharmaceuticals. Liposomes possess particular properties such as biocompatibility, biodegradability;
L D Mayer et al.
Biochimica et biophysica acta, 1025(2), 143-151 (1990-06-27)
Studies from this laboratory (Mayer et al. (1986) Biochim. Biophys. Acta 857, 123-126) have shown that doxorubicin can be accumulated into liposomal systems in response to transmembrane pH gradients (inside acidic). Here, detailed characterizations of the drug uptake and retention
A L Klibanov et al.
FEBS letters, 268(1), 235-237 (1990-07-30)
Incorporation of dioleoyl N-(monomethoxy polyethyleneglycol succinyl)phosphatidylethanolamine (PEG-PE) into large unilamellar liposomes composed of egg phosphatidylcholine:cholesterol (1:1) does not significantly increase the content leakage when the liposomes are exposed to 90% human serum at 37 degrees C, yet the liposomes show
Notre équipe de scientifiques dispose d'une expérience dans tous les secteurs de la recherche, notamment en sciences de la vie, science des matériaux, synthèse chimique, chromatographie, analyse et dans de nombreux autres domaines..
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