900847

4-(Fluorosulfonyl)-3-((trimethylsilyl)ethynyl)benzoic acid

≥95%

• Synonyme(s) : Carboxyl sulfonyl fluoride TMS-alkyne, Probe building block
• Formule empirique (notation de Hill): C₁₂H₁₃FO₄SSi
• Numéro CAS: 2088828-92-4
• Poids moléculaire : 300.38
• Code UNSPSC : 12352106
• Nomenclature NACRES : NA.22

Propriétés

• Pureté: ≥95%
• Forme: powder or crystals
• Température de stockage: −20°C
• Chaîne SMILES: OC(C1=CC(C#C[Si](C)(C)C)=C(S(F)(=O)=O)C=C1)=O

Description

Application

4-(Fluorosulfonyl)-3-((trimethylsilyl)ethynyl)benzoic acid is used for chemical probe synthesis, this trifunctional building block contains an aryl sulfonyl fluoride group, alkyne tag, and carboxylic acid synthetic handle. When appended to a ligand or pharmacophore through its acid linker, this building block allows for SuFEx-enabled, context-specific covalent modification of a biological target with potential for downstream applications via the alkyne tag. Use alone or in parallel with other multi-functional building blocks to discover the optimal probe for your chemical biology experiments.

Autres remarques

Technology Spotlight: Trifunctional Probe Building Blocks
Chemoselective Preparation of Clickable Aryl Sulfonyl Fluoride Monomers: A Toolbox of Highly Functionalized Intermediates for Chemical Biology Probe Synthesis

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable