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Merck

HTR2B

5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled

Synonymes:
5-HT(2B), 5-HT2B
Espèce(s):
Human HTR2B (3357), Mouse Htr2b (15559), Rat Htr2b (29581), chicken HTR2B (395581), Zebrafish htr2b (751784), dog HTR2B (403881), cow HTR2B (407135), Horse HTR2B (100057052), domestic cat HTR2B (101095762), Domestic Rabbit HTR2B (100343392) ...Plus
ID UniProtKB:
P41595, B2R9D5, Q53TI1, Q62221, Q6P523
ID du gène:
  • Human(3357) Summary: This gene encodes one of the several different receptors for 5-hydroxytryptamine (serotonin) that belongs to the G-protein coupled receptor 1 family. Serotonin is a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. Serotonin receptors mediate many of the central and peripheral physiologic functions of serotonin, including regulation of cardiovascular functions and impulsive behavior. Population and family-based analyses of a minor allele (glutamine-to-stop substitution, designated Q20*) which blocks expression of this protein, and knockout studies in mice, suggest a role for this gene in impulsivity. However, other factors, such as elevated testosterone levels, may also be involved. [provided by RefSeq, Oct 2011]
  • Mouse(15559) 5-hydroxytryptamine (serotonin) receptor 2B
  • Rat(29581) 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
  • chicken(395581) 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
  • Zebrafish(751784) 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
  • dog(403881) 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
  • cow(407135) 5-hydroxytryptamine (serotonin) receptor 2B
  • Horse(100057052) 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
  • domestic cat(101095762) 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
  • Domestic Rabbit(100343392) 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
  • sheep(101106827) 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
  • naked mole-rat(101699201) 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
  • domestic guinea pig(100135546) 5-hydroxytryptamine (serotonin) receptor 2B

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Small Molecule - Agonist

Référence du produit
Description
Espèce(s)
B175
BW 723C86, ≥98% (HPLC),
Espèce(s)
human
1430000
Methylergonovine maleate, United States Pharmacopeia (USP) Reference Standard,
Espèce(s)
human
Y0000776
Methylergometrine maleate, European Pharmacopoeia (EP) Reference Standard,
Espèce(s)
human
Y0000777
Methylergometrine for system suitability, European Pharmacopoeia (EP) Reference Standard,
Espèce(s)
human
D101
(±)-DOI hydrochloride, ≥98% (HPLC), solid,
Espèce(s)
human

Small Molecule - Allosteric Modulator

Référence du produit
Description
Espèce(s)
D9190
DCEBIO, ≥98% (HPLC), solid,
Espèce(s)
human

Small Molecule - Antagonist

Référence du produit
Description
Espèce(s)
1430000
Methylergonovine maleate, United States Pharmacopeia (USP) Reference Standard,
Espèce(s)
human
Y0000776
Methylergometrine maleate, European Pharmacopoeia (EP) Reference Standard,
Espèce(s)
human
Y0000777
Methylergometrine for system suitability, European Pharmacopoeia (EP) Reference Standard,
Espèce(s)
human
S006
Ketanserin (+)-tartrate salt, ≥97%, solid,
Espèce(s)
human
C4542
Cyclobenzaprine hydrochloride, ,
Espèce(s)
human

Antibodies

Référence du produit
Description
Espèces réactives
Application
HPA012867
Anti-HTR2B antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Espèces réactives
human
Application
immunofluorescence
immunohistochemistry
HPA063658
Anti-HTR2B antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Espèces réactives
human
Application
immunofluorescence
SAB4501476
Anti-HTR2B antibody produced in rabbit, affinity isolated antibody,
Espèces réactives
human
Application
ELISA
immunofluorescence
western blot
SAB4501475
Anti-5-HT-2B antibody produced in rabbit, affinity isolated antibody,
Espèces réactives
human
Application
ELISA
immunofluorescence
immunohistochemistry
western blot
AMAB91972
Monoclonal Anti-Htr2B Antibody Produced In Mouse, Prestige Antibodies® Powered by Atlas Antibodies, clone CL14576, affinity isolated antibody, buffered aqueous glycerol solution,
Espèces réactives
human
Application
western blot

Small Molecule - Blocker

Référence du produit
Description
Espèce(s)
M2525
Mianserin hydrochloride, ,
Espèce(s)
human
T3146
Trimipramine maleate salt, ≥98% (TLC), powder,
Espèce(s)
human
Z101
Zimelidine dihydrochloride, solid,
Espèce(s)
human

Small Molecule - Inhibitor

Référence du produit
Description
Espèce(s)
N7261
Nortriptyline hydrochloride, ≥98% (HPLC), powder,
Espèce(s)
human
A129
Amoxapine, ,
Espèce(s)
human
F1553
S-(+)-Fluoxetine hydrochloride, ≥98% (HPLC), solid,
Espèce(s)
human
F1678
R-(−)-Fluoxetine hydrochloride, >98% (HPLC), solid,
Espèce(s)
human
F132
Fluoxétine hydrochloride, solid,
Espèce(s)
human

Small Molecule - Ligand

Référence du produit
Description
Espèce(s)
M1514
Nω-Methyl-5-hydroxy­trypt­amine oxalate salt, ≥90% (HPLC),
Espèce(s)
human

Small Molecule - Metabolite

Référence du produit
Description
Espèce(s)
H8876
5-Hydroxyindole-3-acetic acid, ≥98% (HPLC), crystalline,
Espèce(s)
human

Small Molecule - Mixed Agonist/Antagonist

Référence du produit
Description
Espèce(s)
M8046
Mifepristone, ≥98%,
Espèce(s)
human, mouse, rat
C6305
Clozapine, ,
Espèce(s)
human, rat

Small Molecule - Precursor

Référence du produit
Description
Espèce(s)
H9772
5-Hydroxy-L-tryptophan, powder,
Espèce(s)
human

esiRNA

Référence du produit
Description
Espèce(s)
EHU052881
MISSION® esiRNA, targeting human HTR2B,
Espèce(s)
human