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Merck

CYP11A1

cytochrome P450, family 11, subfamily A, polypeptide 1

Synonymes:
CYP11A, CYPXIA1, P450SCC
Espèce(s):
Human CYP11A1 (1583), Mouse Cyp11a1 (13070), Rat Cyp11a1 (29680), sheep CYP11A1 (100048994), Domestic Rabbit CYP11A1 (100345737), cow CYP11A1 (338048), Zebrafish cyp11a1 (80374), chicken CYP11A1 (414838), Horse CYP11A1 (100034229), dog CYP11A1 (478365)
ID UniProtKB:
P05108, A8K8D5, B3KPU8, G3XAD7, Q15081, Q16805, Q8N1A7
ID du gène:
  • Human(1583) Summary: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane and catalyzes the conversion of cholesterol to pregnenolone, the first and rate-limiting step in the synthesis of the steroid hormones. Two transcript variants encoding different isoforms have been found for this gene. The cellular location of the smaller isoform is unclear since it lacks the mitochondrial-targeting transit peptide. [provided by RefSeq, Jul 2008]
  • Mouse(13070) cytochrome P450, family 11, subfamily a, polypeptide 1
  • Rat(29680) cytochrome P450, family 11, subfamily a, polypeptide 1
  • sheep(100048994) cytochrome P450, family 11, subfamily A, polypeptide 1
  • Domestic Rabbit(100345737) cytochrome P450, family 11, subfamily A, polypeptide 1
  • cow(338048) cytochrome P450, family 11, subfamily A, polypeptide 1
  • Zebrafish(80374) cytochrome P450, subfamily XIA, polypeptide 1
  • chicken(414838) cytochrome P450, family 11, subfamily A, polypeptide 1
  • Horse(100034229) cytochrome P450 cholesterol side-chain cleavage
  • dog(478365) cytochrome P450, family 11, subfamily A, polypeptide 1

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Antibodies

Référence du produit
Description
Espèces réactives
Application
ZRB2822
Anti-CYP11A1 Antibody, clone 2M5 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Espèces réactives
chimpanzee, human
Application
affinity binding assay
immunofluorescence
immunohistochemistry
western blot
HPA016436
Anti-CYP11A1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Espèces réactives
human
Application
immunohistochemistry
ABS236
Anti-Cytochrome P450 (scc) Antibody, a.a. 509-526, from rabbit, purified by affinity chromatography,
Espèces réactives
rat
Application
immunohistochemistry
western blot
SAB1405692
Anti-CYP11A1 antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
Espèces réactives
human
Application
western blot

Small Molecule - Inhibitor

Référence du produit
Description
Espèce(s)
1445007
1-(2-Chlorophenyl)-1-(4-chlorophenyl)-2,2-dichloroethane, United States Pharmacopeia (USP) Reference Standard,
Espèce(s)
human
35485
2,4′-DDD, PESTANAL®, analytical standard,
Espèce(s)
human
A9657
DL-Aminoglutethimide, ,
Espèce(s)
human, rat

esiRNA

Référence du produit
Description
Espèce(s)
EHU143581
MISSION® esiRNA, targeting human CYP11A1,
Espèce(s)
human
EMU079961
MISSION® esiRNA, targeting mouse Cyp11a1,
Espèce(s)
mouse