CHEK2
checkpoint kinase 2
Synonymes:
CDS1, CHK2, HuCds1, LFS2, PP1425, RAD53, hCds1
Espèce(s):
Human CHEK2 (11200), Mouse Chek2 (50883), Rat Chek2 (114212), domestic guinea pig Chek2 (100727440), sheep CHEK2 (101105532), cow CHEK2 (518897), domestic cat CHEK2 (101085665), Horse CHEK2 (100059288), dog CHEK2 (486338), chicken CHEK2 (768913) ...Plus
ID UniProtKB:
ID du gène:
- Human(11200) Summary: In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by this gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the encoded protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53. Also, mutations in this gene are thought to confer a predisposition to sarcomas, breast cancer, and brain tumors. This nuclear protein is a member of the CDS1 subfamily of serine/threonine protein kinases. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
- Mouse(50883) checkpoint kinase 2
- Rat(114212) checkpoint kinase 2
- domestic guinea pig(100727440) checkpoint kinase 2
- sheep(101105532) checkpoint kinase 2
- cow(518897) CHK2 checkpoint homolog (S. pombe)
- domestic cat(101085665) checkpoint kinase 2
- Horse(100059288) checkpoint kinase 2
- dog(486338) checkpoint kinase 2
- chicken(768913) checkpoint kinase 2
- Zebrafish(336998) CHK2 checkpoint homolog (S. pombe)
- naked mole-rat(101721212) checkpoint kinase 2
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Antibodies
Référence du produit
Description
Espèces réactives
Application
Anti-phospho-Chk2 (pThr68) antibody produced in rabbit, affinity isolated antibody,
Espèces réactives
human, mouse, rat
Application
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-Chk2 Antibody, clone 7, clone 7, Upstate®, from mouse,
Espèces réactives
human, mouse
Application
immunocytochemistry
immunoprecipitation (IP)
western blot
immunoprecipitation (IP)
western blot
Monoclonal Anti-Chk2 antibody produced in mouse, clone DCS-270, purified from hybridoma cell culture,
Espèces réactives
human
Application
immunocytochemistry
immunohistochemistry
immunoprecipitation (IP)
microarray
western blot
immunohistochemistry
immunoprecipitation (IP)
microarray
western blot
Anti-phospho-Chk2 (pThr387) antibody produced in rabbit, affinity isolated antibody,
Espèces réactives
human, mouse, rat
Application
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-CHEK2 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Espèces réactives
human
Application
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot
Small Molecule - Inhibitor
Référence du produit
Description
Espèce(s)
Proteins
Référence du produit
Description
Espèce(s)
CHK2 active human, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE),
Espèce(s)
human
CHK2 Protein, active, 10 µg, Active, recombinant human CHK2, residues 5-543, containing N-terminal GST & C-terminal His-6 tags, for use in Kinase Assays.,
Espèce(s)
human