Journal of translational medicine, 13, 199-199 (2015-06-25)
Clinical therapy for metastatic colorectal cancer (CRC) remains limited, especially when the tumor harbors a KRAS mutation. This study aimed to identify prognostic biomarkers in CRC that are accessible for therapeutic inhibition. Conditioned media from human CRC epithelial cells and
Much research has gone into the development of hybrid gene delivery systems that combine the broad tropism and efficient transduction of adenoviral vectors with the ability to achieve stable expression of cargo genes. In addition to gene therapy applications, such
The forkhead domain FOXP2 and FOXP1 transcription factors are implicated in several cognitive disorders with language deficits, notably autism, and thus play a central role in learned vocal motor behavior in humans. Although a similar role for FoxP2 and FoxP1
Targeting drug delivery to invasive glioma cells is a particularly difficult challenge because these cells lie behind an intact blood-brain barrier (BBB) that can be observed using multimodality imaging. BBB-associated efflux transporters such as P-glycoprotein (P-gp) and breast cancer resistance
Cephalopods can display dazzling patterns of colours by selectively contracting muscles to reversibly activate chromatophores--pigment-containing cells under their skins. Inspired by this novel colouring strategy found in nature, we design an electro-mechano-chemically responsive elastomer system that can exhibit a wide
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