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The cytotoxicity of 2-bromoethanol towards hepatocytes isolated from rats was concentration-dependent (EC(50)100 mu M, 2 hr). Bromoacetaldehyde was more toxic (EC(50)60 mu M, 2 hr) and bromoacetic acid was less toxic (EC(50)150 mu M, 2 hr). Glutathione (GSH) depletion occurred
Zeitschrift fur Lebensmittel-Untersuchung und -Forschung, 189(1), 21-25 (1989-07-01)
This study describes a headspace gas-chromatographic method for the quantitative determination of inorganic bromide in vegetables. Different parameters influencing the reaction of the bromide ion into 2-bromoethanol have been investigated. The analysis of 2-bromoethanol is performed by the headspace--electron capture--gas
The cytotoxicity of dibromoalkanes to isolated hepatocytes was proportional to the dibromoalkane concentration and increasing chain length of the dibromoalkane (C2-C6). The rapid hepatocyte glutathione (GSH) depletion which occurred upon addition of the dibromoalkanes was also dependent on the concentration
The journal of physical chemistry. A, 115(51), 14559-14569 (2011-11-11)
This work characterizes the internal energy distribution of the CD(2)CD(2)OH radical formed via photodissociation of 2-bromoethanol-d(4). The CD(2)CD(2)OH radical is the first radical adduct in the addition of the hydroxyl radical to C(2)D(4) and the product branching of the OH
Xenobiotica; the fate of foreign compounds in biological systems, 11(11), 763-770 (1981-11-01)
1. The metabolism of 2-bromo[U-14C]ethanol an [U-14C]ethylene oxide has been studied in the rat. 2. As both compounds give rise to similar amounts of two urinary metabolites, identified as S-(2-hydroxyethyl)cysteine and N-acetyl-S-(2-hydroxyethyl)cysteine, it is proposed that 2-bromoethanol is converted into
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