SRP3279
BMP-5 human
recombinant, expressed in CHO cells, ≥95% (SDS-PAGE), ≥95% (HPLC)
Synonym(s):
none
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About This Item
UNSPSC Code:
12352202
NACRES:
NA.32
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biological source
human
recombinant
expressed in CHO cells
Assay
≥95% (HPLC)
≥95% (SDS-PAGE)
form
lyophilized
potency
0.5-1.0 μg/mL ED50
mol wt
31.2 kDa
packaging
pkg of 10 μg
impurities
<0.1 EU/μg endotoxin, tested
color
white to off-white
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... BMP5(653)
Related Categories
General description
As implied by their name, BMPs initiate, promote, and regulate the development, growth and remodeling of bone and cartilage. In addition to this role, BMPs are also involved in prenatal development and postnatal growth, remodeling and maintenance of a variety of other tissues and organs.
Biochem/physiol Actions
TGF-β family members are key modulators of cell proliferation, differentiation, matrix synthesis, and apoptosis. BMP-5 is expressed in the nervous system, lung and liver. It is a known regulator for dendritic growth in sympathetic neurons. BMP-5 is a 454 amino acid precursor protein that is cleaved to release the biologically active C-terminal mature protein. Recombinant human BMP-5 is a 15.6 kDa homodimeric disulfide-linked protein consisting of two identical 138 amino acid chains.
Physical form
Lyophilized with no additives.
Reconstitution
Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/mL. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.
Storage Class Code
10 - Combustible liquids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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Di Chen et al.
Growth factors (Chur, Switzerland), 22(4), 233-241 (2004-12-29)
Bone morphogenetic proteins (BMPs) are multi-functional growth factors that belong to the transforming growth factor beta (TGFbeta) superfamily. The roles of BMPs in embryonic development and cellular functions in postnatal and adult animals have been extensively studied in recent years.
Elina V García et al.
Theriogenology, 84(4), 589-599 (2015-05-28)
Previous studies have reported that bone morphogenetic protein 5 (BMP5) is differentially expressed in the isthmus of bovine oviducts and it is present in the oviductal fluid. However, the specific action of this factor is unknown. To evaluate whether BMP5
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