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Key Documents

SRP0418

Sigma-Aldrich

WDR5 human

recombinant, expressed in baculovirus infected Sf9 cells, ≥90% (SDS-PAGE)

Synonym(s):

BIG-3, SWD3, WD Repeat Domain 5

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100 μG
CHF 629.00

CHF 629.00

Estimated to ship on26 April 2025

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100 μG
CHF 629.00

About This Item

UNSPSC Code:
12352202
NACRES:
NA.32

CHF 629.00

Estimated to ship on26 April 2025

biological source

human

recombinant

expressed in baculovirus infected Sf9 cells

Assay

≥90% (SDS-PAGE)

form

aqueous solution

mol wt

37.5 kDa

packaging

pkg of 100 μg

NCBI accession no.

NM_017588

UniProt accession no.

P61964

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... WDR5(11091)

General description

Human WDR5 (WD Repeat Domain 5), also known as SWD3 or BIG-3 (GenBank Accession No. NM_017588) amino acids 2-334 (end) with N-terminal His-tag, MW=37.5 kDa, expressed in Sf9 insect cells via a Baculovirus expression system.

Application

Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.

Pictograms

Health hazardExclamation mark
GHS08,GHS07

Signal Word

Danger

Hazard Statements

H315,H319,H360D

Hazard Classifications

Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2

Storage Class Code

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
7120001011

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WDR5, a complexed protein.
Raymond C Trievel et al.
Nature structural & molecular biology, 16(7), 678-680 (2009-07-07)
Yan-Yi Wang et al.
Proceedings of the National Academy of Sciences of the United States of America, 107(2), 815-820 (2010-01-19)
Viral infection causes activation of the transcription factors NF-kappaB and IRF3, which collaborate to induce type I interferons (IFNs) and cellular antiviral response. The mitochondrial outer membrane protein VISA acts as a critical adapter for assembling a virus-induced complex that
Zain Odho et al.
The Journal of biological chemistry, 285(43), 32967-32976 (2010-08-19)
Histone modification is well established as a fundamental mechanism driving the regulation of transcription, replication, and DNA repair through the control of chromatin structure. Likewise, it is apparent that incorrect targeting of histone modifications contributes to misregulated gene expression and

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