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SML1389

Sigma-Aldrich

Farrerol

≥98% (HPLC)

Synonym(s):

(-)-Farrerol, (S)-2,3-Dihydro-5,7-dihydroxy-2-(4-hydroxyphenyl)-6,8-dimethyl-4-benzopyrone, 4′,5,7-Trihydroxy 6,8-dimethylflavanone, CID 442396

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About This Item

Empirical Formula (Hill Notation):
C17H16O5
CAS Number:
24211-30-1
Molecular Weight:
300.31
EC Number:
246-080-2
MDL number:
MFCD28347824
UNSPSC Code:
12352200
PubChem Substance ID:
329825837
NACRES:
NA.77

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 20 mg/mL, clear

storage temp.

2-8°C

SMILES string

CC1=C(O)C(C)=C(O)C2=C1O[C@H](C3=CC=C(O)C=C3)CC2=O

InChI

1S/C17H16O5/c1-8-15(20)9(2)17-14(16(8)21)12(19)7-13(22-17)10-3-5-11(18)6-4-10/h3-6,13,18,20-21H,7H2,1-2H3/t13-/m0/s1

InChI key

DYHOLQACRGJEHX-ZDUSSCGKSA-N

Biochem/physiol Actions

Antibechic, anti-bacterial, anti-inflammatory
Farrerol is major bioactive component from Rhododendron dauricum L. (Man-Shan-Hong). Farrerol exhibits numerous activities including antibechic, anti-bacterial, anti-inflammatory and inhibition of vascular smooth muscle cells (VSMC) proliferation. Recent study shows that Farrerol regulates occludin expression by preventing H2O2-induced activation ERK 1/2 in human endothelium-derived EA.hy926 cells.

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
085M4758V

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Weina Zhang et al.
eLife, 9 (2020-07-10)
Directly modulating the choice between homologous recombination (HR) and non-homologous end joining (NHEJ) - two independent pathways for repairing DNA double-strand breaks (DSBs) - has the potential to improve the efficiency of gene targeting by CRISPR/Cas9. Here, we have developed

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