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SAB4503558

Sigma-Aldrich

Anti-RABEP1 antibody produced in rabbit

affinity isolated antibody

Synonym(s):

Rabaptin-4, Rabaptin-5, Rabaptin-5α, Renal carcinoma antigen NY-REN-17

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 99 kDa

species reactivity

human, rat, mouse

concentration

~1 mg/mL

technique(s)

ELISA: 1:40000
immunohistochemistry: 1:50-1:100

NCBI accession no.

Q15276

UniProt accession no.

Q15276

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... RABEP1(9135)

Related Categories

General description

Anti-RABEP1 Antibody detects endogenous levels of total RABEP1 protein.
The gene RABEP1 (Rab GTPase-binding effector protein 1) is mapped to human chromosome 17p13.2. The encoded protein has two Rab5-binding sites.

Immunogen

The antiserum was produced against synthesized peptide derived from human RABEP1.

Immunogen Range: 549-598

Biochem/physiol Actions

RABEP1 (Rab GTPase-binding effector protein 1) is an effector of Rab5 and plays an important role in homotypic and heterotypic fusions of early endosomes. Absence of RABEP1 suppresses Rab5-associated early endosome fusion.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

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Storage Class Code

10 - Combustible liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

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Zhe Zhang et al.
eLife, 3, doi:10-doi:10 (2014-06-25)
Rabex-5 and Rabaptin-5 function together to activate Rab5 and further promote early endosomal fusion in endocytosis. The Rabex-5 GEF activity is autoinhibited by the Rabex-5 CC domain (Rabex-5CC) and activated by the Rabaptin-5 C2-1 domain (Rabaptin-5C21) with yet unknown mechanism.
PDGFRB-rearranged T-lymphoblastic leukemia/lymphoma occurring with myeloid neoplasms: the missing link supporting a stem cell origin.
Sarah L Ondrejka et al.
Haematologica, 99(9), e148-e151 (2014-06-22)
Mi Hee Park et al.
Experimental & molecular medicine, 47, e200-e200 (2015-12-19)
Endocytosis is differentially regulated by hypoxia-inducible factor-1α (HIF-1α) and phospholipase D (PLD). However, the relationship between HIF-1α and PLD in endocytosis is unknown. HIF-1α is degraded through the prolyl hydroxylase (PHD)/von Hippel-Lindau (VHL) ubiquitination pathway in an oxygen-dependent manner. Here

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