SAB4502062

Anti-PAK1 antibody produced in rabbit

affinity isolated antibody

• Synonym(s): α-PAK, PAK-1, Serine/threonine-protein kinase PAK 1, p21-activated kinase 1, p65-PAK
• MDL number: MFCD03455286
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: antigen 60 kDa
• species reactivity: mouse, rat, human
• concentration: ~1 mg/mL
• technique(s): ELISA: 1:1000; immunofluorescence: 1:100-1:500; immunohistochemistry: 1:50-1:100; western blot: 1:500-1:1000
• NCBI accession no.: Q13153
• UniProt accession no.: Q13153
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... PAK1(5058)

Description

General description

Anti-PAK1 antibody detects endogenous levels of total PAK1 protein.

The PAK1 (p21 (RAC1) activated kinase 1) gene is mapped to human chromosome 11q13.5-q14.1. It belongs to the family of serine/threonine kinases and the gene is evolutionarily conserved.

Immunogen

The antiserum was produced against synthesized peptide derived from human PAK1.

Immunogen Range: 178-227

Biochem/physiol Actions

PAK1 (p21 (RAC1) activated kinase 1) maintains the cytoskeleton and cellular morphology. It is associated with cell cycle, cell motility, survival, and cell death. PAK1 is upregulated in different types of cancer. PAK1 is found to be involved in growth, invasion, and metastasis of cancer cells, as it affects the action of pro-apoptotic signals. In neurodegenerative diseases, such as Huntington′s disease and Alzheimer′s disease, and mental retardation, abnormal regulation of PAK1 is observed. PAK1 induces MAPK (mitogen activated protein kinase) signal pathway and cytoskeletal remodeling in breast cancer, thereby serving as an oncogene. PAK1 is known to significantly participate in the development, maturation and plasticity of the nervous system.

Features and Benefits

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Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: nwg
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable