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Key Documents

SAB1409291

Sigma-Aldrich

Monoclonal Anti-CUEDC1 antibody produced in mouse

clone 4F9, purified immunoglobulin, buffered aqueous solution

Synonym(s):

DKFZp547L163, FLJ20739

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100 μG
CHF 474.00

CHF 474.00

Estimated to ship on24 April 2025

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100 μG
CHF 474.00

About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

CHF 474.00

Estimated to ship on24 April 2025

biological source

mouse

Quality Level

100

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

4F9, monoclonal

form

buffered aqueous solution

mol wt

antigen 68.7 kDa

species reactivity

human

technique(s)

indirect ELISA: suitable
western blot: 1-5 μg/mL

isotype

IgG2aκ

NCBI accession no.

NM_017949.1

UniProt accession no.

Q9NWM3

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... CUEDC1(404093)

Immunogen

CUEDC1 (NP_060419.1, 1 a.a. ~ 386 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Sequence
MTSLFRRSSSGSGGGGTAGARGGGGGTAAPQELNNSRPARQVRRLEFNQAMDDFKTMFPNMDYDIIECVLRANSGAVDATIDQLLQMNLEGGGSSGGVYEDSSDSEDSIPPEILERTLEPDSSDEEPPPVYSPPAYHMHVFDRPYPLAPPTPPPRIDALGSGAPTSQRRYRNWNPPLLGNLPDDFLRILPQQLDSIQGNAGGPKPGSGEGCPPAMAGPGPGDQESRWKQYLEDERIALFLQNEEFMKELQRNRDFLLALERDRLKYESQKSKSSSVAVGNDFGFSSPVPGTGDANPAVSEDALFRDKLKHMGKSTRRKLFELARAFSEKTKMRKSKRKHLLKHQSLGAAASTANLLDDVEGHACDEDFRGRRQEAPKVEEGLREGQ

Biochem/physiol Actions

CUEDC1 (CUE domain containing 1) might be involved in protein trafficking and degradation. Changes in this gene are linked with early stage cervical cancer. It is highly methylated in the placental tissue of preeclampsia patients. CUEDC1 is suggested to control trophoblast invasion by participating in the TGF (transforming growth factor)-β/Smad (mothers against decapentaplegic homolog) signaling pathway. The gene is mapped to human chromosome 17q23.

Physical form

Solution in phosphate buffered saline, pH 7.4

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Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
11259-4F9

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Y-H Yan et al.
European review for medical and pharmacological sciences, 17(22), 3083-3094 (2013-12-05)
Preeclampsia is a complication of pregnancy that severely threatens the health of the mother and infant, yet the mechanism of pathogenesis remains unclear. In this article, gene array technology was applied to identify the genes related to the pathogenesis of

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